The insulin-like growth factor system in kidney diseases

Erick J. Richmond, Amira Al-Uzri, A. D. Rogol

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The insulin-like growth factor system is intimately involved in renal development, growth, function and the pathophysiology of several disease states. Exogenous IGF-I increases GFR and RPF, perhaps mediated by nitric oxide (NO). In chronic renal failure, IGF-I, the binding proteins and their fragments decrease bioavailability. After transplantation, the levels of bioactive IGF-I increase likely due to better nutrition and increased clearance of the binding proteins and their fragments. In the nephritic syndrome, a similar mechanism may be active, in that the binding proteins and their fragments may inhibit IGF-I action.

Original languageEnglish (US)
Pages (from-to)5-9
Number of pages5
JournalNephron
Volume89
Issue number1
DOIs
Publication statusPublished - 2001
Externally publishedYes

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Keywords

  • Chronic renal failure
  • IGF-I
  • IGFBPs
  • Nephritic syndrome
  • Renal development

ASJC Scopus subject areas

  • Nephrology

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