The insulin-like growth factor I generation test in the investigation of short stature.

A. M. Cotterill, C. Camacho-Hübner, Kathryn (Katie) Woods, C. Martinelli, P. Duquesnoy, M. O. Savage

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Genotypic and phenotypic heterogeneity in patients with growth hormone (GH) insensitivity syndrome suggests that partial defects exist in the GH receptor. The insulin-like growth factor I (IGF-I) generation test was assessed as a means of identifying partial GH receptor defects in a heterogeneous group of 22 prepubertal children with short stature. In a subgroup of nine patients with peak GH levels of 63.7 +/- 3.7 mU/l during a glucagon tolerance test, the response to the IGF-I generation test was no different from that for the group as a whole (peak GH, 43.3 +/- 4.5 mU/l), despite the fact that this subgroup exhibited a negative relationship between height SDS and peak GH and a positive relationship between height SDS and IGF binding protein-3. This preliminary study therefore suggests that the IGF-I generation test in its present form will not be useful as a primary screening test for partial GH insensitivity. Despite this, the IGF-I generation test has been extremely useful in the confirmation of the diagnosis of GHIS and may therefore also prove useful in the confirmation of partial defects in the GH receptor. A subgroup of short children with peak GH levels above 40 mU/l had some characteristics of partial GH receptor deficiency. These children, to whom GH therapy would not normally be given, may respond better to recombinant human IGF-I.

Original languageEnglish (US)
Pages (from-to)128-130
Number of pages3
JournalActa paediatrica (Oslo, Norway : 1992). Supplement
Volume399
StatePublished - Apr 1994
Externally publishedYes

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Laron Syndrome
Insulin-Like Growth Factor I
Growth Hormone
Somatotropin Receptors
Insulin-Like Growth Factor Binding Protein 3
Glucagon

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Cotterill, A. M., Camacho-Hübner, C., Woods, K. K., Martinelli, C., Duquesnoy, P., & Savage, M. O. (1994). The insulin-like growth factor I generation test in the investigation of short stature. Acta paediatrica (Oslo, Norway : 1992). Supplement, 399, 128-130.

The insulin-like growth factor I generation test in the investigation of short stature. / Cotterill, A. M.; Camacho-Hübner, C.; Woods, Kathryn (Katie); Martinelli, C.; Duquesnoy, P.; Savage, M. O.

In: Acta paediatrica (Oslo, Norway : 1992). Supplement, Vol. 399, 04.1994, p. 128-130.

Research output: Contribution to journalArticle

Cotterill, AM, Camacho-Hübner, C, Woods, KK, Martinelli, C, Duquesnoy, P & Savage, MO 1994, 'The insulin-like growth factor I generation test in the investigation of short stature.', Acta paediatrica (Oslo, Norway : 1992). Supplement, vol. 399, pp. 128-130.
Cotterill, A. M. ; Camacho-Hübner, C. ; Woods, Kathryn (Katie) ; Martinelli, C. ; Duquesnoy, P. ; Savage, M. O. / The insulin-like growth factor I generation test in the investigation of short stature. In: Acta paediatrica (Oslo, Norway : 1992). Supplement. 1994 ; Vol. 399. pp. 128-130.
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