TY - JOUR
T1 - The 'ins' and 'outs' of podosomes and invadopodia
T2 - Characteristics, formation and function
AU - Murphy, Danielle A.
AU - Courtneidge, Sara A.
N1 - Funding Information:
We are grateful to B. Diaz, M. Buschman and C. Gould for reading the manuscript and to J. Tsai for help in figure preparation. The Courtneidge laboratory is supported by grants from the National Cancer Institute, National Institutes of Health, USA, and the Mathers Foundation, New York, USA. D.A.M. is supported by training grant T32CA121949 and The American Cancer Society North Texas Postdoctoral Fellowship, 2008 (North Texas Creating Tomorrow’s Miracles).
PY - 2011/6
Y1 - 2011/6
N2 - Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane of metazoan cells that represent sites of attachment to - and degradation of - the extracellular matrix. The key proteins in these structures include the actin regulators cortactin and neural Wiskott-Aldrich syndrome protein (N-WASP), the adaptor proteins Tyr kinase substrate with four SH3 domains (TKS4) and Tyr kinase substrate with five SH3 domains (TKS5), and the metalloprotease membrane type 1 matrix metalloprotease (MT1MMP; also known as MMP14). Many cell types can produce these structures, including invasive cancer cells, vascular smooth muscle and endothelial cells, and immune cells such as macrophages and dendritic cells. Recently, progress has been made in our understanding of the regulatory and functional aspects of podosome and invadopodium biology and their role in human disease.
AB - Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane of metazoan cells that represent sites of attachment to - and degradation of - the extracellular matrix. The key proteins in these structures include the actin regulators cortactin and neural Wiskott-Aldrich syndrome protein (N-WASP), the adaptor proteins Tyr kinase substrate with four SH3 domains (TKS4) and Tyr kinase substrate with five SH3 domains (TKS5), and the metalloprotease membrane type 1 matrix metalloprotease (MT1MMP; also known as MMP14). Many cell types can produce these structures, including invasive cancer cells, vascular smooth muscle and endothelial cells, and immune cells such as macrophages and dendritic cells. Recently, progress has been made in our understanding of the regulatory and functional aspects of podosome and invadopodium biology and their role in human disease.
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U2 - 10.1038/nrm3141
DO - 10.1038/nrm3141
M3 - Review article
C2 - 21697900
AN - SCOPUS:79959541003
SN - 1471-0072
VL - 12
SP - 413
EP - 426
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 7
ER -