The initial acute phase response predicts long-term stroke recovery

Wayne Clark, Nancy B. Beamer, Michael Wynn, Bruce M. Coull

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Indicators of an acute phase response (APR) in acute ischemic stroke have been shown to correlate with infarct size and predict stroke recurrence. In this study, we examined how well the APR indicators predicted long-term stroke recovery compared with standard clinical predictors of recovery. Plasma levels of interleukin-6 (IL-6), fibrinogen, white blood cells (WBCs), and serum albumin were measured within 4±2 days of onset in 131 stroke patients who were free of apparent infections. Standard clinical predictors included initial National Institutes of Health Stroke Scale (NIHSS), infarct size on computed tomography (CT), and Glasgow scale. The individual correlations with 6-month Glasgow outcome were IL-6, 0.42; fibrinogen, 0.24; WBC, 0.35; albumin, 0.47; NIHSS, 0.53; infarct size, 0.19; and initial Glasgow, 0.57. (all P2 of .31 for the APR indicators, compared with .38 for the clinical variables. These results indicate that the initial APR is highly correlated with 6-month stroke recovery and that this correlation approaches that observed with standard clinical predictors.

Original languageEnglish (US)
Pages (from-to)128-131
Number of pages4
JournalJournal of Stroke and Cerebrovascular Diseases
Volume7
Issue number2
DOIs
StatePublished - Mar 1998

Fingerprint

Acute-Phase Reaction
Stroke
National Institutes of Health (U.S.)
Fibrinogen
Interleukin-6
Leukocytes
Serum Albumin
Albumins
Tomography
Recurrence
Infection
Serum

Keywords

  • Cytokines
  • Interleukin-6
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Rehabilitation
  • Cardiology and Cardiovascular Medicine

Cite this

The initial acute phase response predicts long-term stroke recovery. / Clark, Wayne; Beamer, Nancy B.; Wynn, Michael; Coull, Bruce M.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 7, No. 2, 03.1998, p. 128-131.

Research output: Contribution to journalArticle

Clark, Wayne ; Beamer, Nancy B. ; Wynn, Michael ; Coull, Bruce M. / The initial acute phase response predicts long-term stroke recovery. In: Journal of Stroke and Cerebrovascular Diseases. 1998 ; Vol. 7, No. 2. pp. 128-131.
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