The influence of valve physiology on outcome following aortic valvotomy for congenital bicuspid valve in children

30-Year results from a single institution

Tara Karamlou, Irving Shen, Bahaaldin Alsoufia, Grant Burch, Mark Reller, Gary (Michael) Silberbach, Ross M. Ungerleider

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: Aortic valvotomy is widely used for the treatment of congenital aortic stenosis in children. We sought to evaluate whether the predominant post-valvotomy physiology, aortic insufficiency (AI) or aortic stenosis (AS) independently affected patient outcome. Methods: From 1972-2002, 57 children with congenital aortic stenosis underwent valvotomy. We divided age-matched patients with residual lesions based on their predominant pathology into three groups: Group I (n=14), patients with moderate AI; Group II (n=14), patients with moderate AS, and Group III (n=14), patients with combined AI and AS. Fifteen patients with severe AI or mild residual lesions following valvotomy were excluded from analysis. Results: mean freedom from aortic valve replacement (AVR) was 11.2±1.7 years in Group I and 21.5±3.9 years in Group II, P=0.05. AVR was required in 11 patients (79%) in Group I vs. only 5 (36%) in Group II, P=0.05. Group III was intermediate, with 9 (64%) requiring AVR. At the time of AVR, patients with aortic stenosis had significantly higher fractional shortening % than those with insufficiency or combined lesions, (Group 1: 38.2±7.9 vs. Group II: 46.3±5.5 vs. Group III: 39.2±3.7, P=0.007). Patients in Group II also had less severely dilated ventricles (mm) than those in the other groups, (Group 1: 50.2±12.5 vs. Group II: 39.5±8.3 vs. Group III: 49.0±8.1, P=0.030). Conclusions: patients with predominant AI following valvotomy are more likely to need AVR sooner than those with residual stenosis without AI. Therefore, cautious use of repeat valvotomy using maneuvers to avoid AI (small balloons), may prolong freedom from aortic valve replacement in those patients with significant residual AS.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalEuropean Journal of Cardio-thoracic Surgery
Volume27
Issue number1
DOIs
StatePublished - Jan 2005

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Mitral Valve
Aortic Valve Stenosis
Aortic Valve
Pathology

Keywords

  • Aortic insufficiency
  • Aortic stenosis
  • Congenital
  • Outcome
  • Valvotomy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

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title = "The influence of valve physiology on outcome following aortic valvotomy for congenital bicuspid valve in children: 30-Year results from a single institution",
abstract = "Objective: Aortic valvotomy is widely used for the treatment of congenital aortic stenosis in children. We sought to evaluate whether the predominant post-valvotomy physiology, aortic insufficiency (AI) or aortic stenosis (AS) independently affected patient outcome. Methods: From 1972-2002, 57 children with congenital aortic stenosis underwent valvotomy. We divided age-matched patients with residual lesions based on their predominant pathology into three groups: Group I (n=14), patients with moderate AI; Group II (n=14), patients with moderate AS, and Group III (n=14), patients with combined AI and AS. Fifteen patients with severe AI or mild residual lesions following valvotomy were excluded from analysis. Results: mean freedom from aortic valve replacement (AVR) was 11.2±1.7 years in Group I and 21.5±3.9 years in Group II, P=0.05. AVR was required in 11 patients (79{\%}) in Group I vs. only 5 (36{\%}) in Group II, P=0.05. Group III was intermediate, with 9 (64{\%}) requiring AVR. At the time of AVR, patients with aortic stenosis had significantly higher fractional shortening {\%} than those with insufficiency or combined lesions, (Group 1: 38.2±7.9 vs. Group II: 46.3±5.5 vs. Group III: 39.2±3.7, P=0.007). Patients in Group II also had less severely dilated ventricles (mm) than those in the other groups, (Group 1: 50.2±12.5 vs. Group II: 39.5±8.3 vs. Group III: 49.0±8.1, P=0.030). Conclusions: patients with predominant AI following valvotomy are more likely to need AVR sooner than those with residual stenosis without AI. Therefore, cautious use of repeat valvotomy using maneuvers to avoid AI (small balloons), may prolong freedom from aortic valve replacement in those patients with significant residual AS.",
keywords = "Aortic insufficiency, Aortic stenosis, Congenital, Outcome, Valvotomy",
author = "Tara Karamlou and Irving Shen and Bahaaldin Alsoufia and Grant Burch and Mark Reller and Silberbach, {Gary (Michael)} and Ungerleider, {Ross M.}",
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T1 - The influence of valve physiology on outcome following aortic valvotomy for congenital bicuspid valve in children

T2 - 30-Year results from a single institution

AU - Karamlou, Tara

AU - Shen, Irving

AU - Alsoufia, Bahaaldin

AU - Burch, Grant

AU - Reller, Mark

AU - Silberbach, Gary (Michael)

AU - Ungerleider, Ross M.

PY - 2005/1

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N2 - Objective: Aortic valvotomy is widely used for the treatment of congenital aortic stenosis in children. We sought to evaluate whether the predominant post-valvotomy physiology, aortic insufficiency (AI) or aortic stenosis (AS) independently affected patient outcome. Methods: From 1972-2002, 57 children with congenital aortic stenosis underwent valvotomy. We divided age-matched patients with residual lesions based on their predominant pathology into three groups: Group I (n=14), patients with moderate AI; Group II (n=14), patients with moderate AS, and Group III (n=14), patients with combined AI and AS. Fifteen patients with severe AI or mild residual lesions following valvotomy were excluded from analysis. Results: mean freedom from aortic valve replacement (AVR) was 11.2±1.7 years in Group I and 21.5±3.9 years in Group II, P=0.05. AVR was required in 11 patients (79%) in Group I vs. only 5 (36%) in Group II, P=0.05. Group III was intermediate, with 9 (64%) requiring AVR. At the time of AVR, patients with aortic stenosis had significantly higher fractional shortening % than those with insufficiency or combined lesions, (Group 1: 38.2±7.9 vs. Group II: 46.3±5.5 vs. Group III: 39.2±3.7, P=0.007). Patients in Group II also had less severely dilated ventricles (mm) than those in the other groups, (Group 1: 50.2±12.5 vs. Group II: 39.5±8.3 vs. Group III: 49.0±8.1, P=0.030). Conclusions: patients with predominant AI following valvotomy are more likely to need AVR sooner than those with residual stenosis without AI. Therefore, cautious use of repeat valvotomy using maneuvers to avoid AI (small balloons), may prolong freedom from aortic valve replacement in those patients with significant residual AS.

AB - Objective: Aortic valvotomy is widely used for the treatment of congenital aortic stenosis in children. We sought to evaluate whether the predominant post-valvotomy physiology, aortic insufficiency (AI) or aortic stenosis (AS) independently affected patient outcome. Methods: From 1972-2002, 57 children with congenital aortic stenosis underwent valvotomy. We divided age-matched patients with residual lesions based on their predominant pathology into three groups: Group I (n=14), patients with moderate AI; Group II (n=14), patients with moderate AS, and Group III (n=14), patients with combined AI and AS. Fifteen patients with severe AI or mild residual lesions following valvotomy were excluded from analysis. Results: mean freedom from aortic valve replacement (AVR) was 11.2±1.7 years in Group I and 21.5±3.9 years in Group II, P=0.05. AVR was required in 11 patients (79%) in Group I vs. only 5 (36%) in Group II, P=0.05. Group III was intermediate, with 9 (64%) requiring AVR. At the time of AVR, patients with aortic stenosis had significantly higher fractional shortening % than those with insufficiency or combined lesions, (Group 1: 38.2±7.9 vs. Group II: 46.3±5.5 vs. Group III: 39.2±3.7, P=0.007). Patients in Group II also had less severely dilated ventricles (mm) than those in the other groups, (Group 1: 50.2±12.5 vs. Group II: 39.5±8.3 vs. Group III: 49.0±8.1, P=0.030). Conclusions: patients with predominant AI following valvotomy are more likely to need AVR sooner than those with residual stenosis without AI. Therefore, cautious use of repeat valvotomy using maneuvers to avoid AI (small balloons), may prolong freedom from aortic valve replacement in those patients with significant residual AS.

KW - Aortic insufficiency

KW - Aortic stenosis

KW - Congenital

KW - Outcome

KW - Valvotomy

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