The influence of dosage regimen on experimental gentamicin nephrotoxicity: Dissociation of peak serum levels from renal failure

W. M. Bennett, C. E. Plamp, D. N. Gilbert, Richard Parker, G. A. Porter

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Peak serum levels of gentamicin were varied in rats by administering a standard nephrotoxic dosage of 40 mg/kg per day in one (QD), two, or three (TID) daily doses. The QD animals had the highest peak serum levels but showed no appreciable increase of serum creatinine concentrations over a 10-day treatment period. The TID rats had the lowest peak serum levels, but, after 10 days of drug administration, the serum creatinine concentration (2.8 ± 0.2 mg/100 ml, mean ± SE) was significantly higher than in control rats (0.6 ± 0.01 mg/100 ml)(P

Original languageEnglish (US)
Pages (from-to)576-580
Number of pages5
JournalJournal of Infectious Diseases
Issue number4
Publication statusPublished - 1979


ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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