The influence of diazepam on the activity of secondary vestibular neurons in the rabbit

Neal H. Barmack; Vito E. Pettorossi

doi:10.1016/0304-3940(80)90022-1

The influence of diazepam on the activity of secondary vestibular neurons in the rabbit

Neal H. Barmack, Vito E. Pettorossi

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3 Scopus citations

Abstract

We have studied the influence of intravenously administered diazepam on the activity of single secondary vestibular neurons in unanesthetized, paralyzed rabbits evoked by sinusoidal angular accelerations about the vertical and longitudinal axes. Intravenous injections of diazepam (20-100 μg/kg) caused a decreased sensitivity of all secondary vestibular neurons which were tested. The reduction in sensitivity was sometimes preceded by a transient increase in excitability which lasted 10-40 sec. The duration of the decreased sensitivity to vestibular stimulation following intravenous injections of diazepam was dose-dependent, lasting 15-60 min. These data suggest that the diazepam-induced reduction of vestibuloocular reflexes is caused, at least in part, by the depressant action of diazepam upon secondary vestibular neurons.

Original language	English (US)
Pages (from-to)	339-344
Number of pages	6
Journal	Neuroscience Letters
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(80)90022-1
State	Published - Mar 1980
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(80)90022-1

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title = "The influence of diazepam on the activity of secondary vestibular neurons in the rabbit",

abstract = "We have studied the influence of intravenously administered diazepam on the activity of single secondary vestibular neurons in unanesthetized, paralyzed rabbits evoked by sinusoidal angular accelerations about the vertical and longitudinal axes. Intravenous injections of diazepam (20-100 μg/kg) caused a decreased sensitivity of all secondary vestibular neurons which were tested. The reduction in sensitivity was sometimes preceded by a transient increase in excitability which lasted 10-40 sec. The duration of the decreased sensitivity to vestibular stimulation following intravenous injections of diazepam was dose-dependent, lasting 15-60 min. These data suggest that the diazepam-induced reduction of vestibuloocular reflexes is caused, at least in part, by the depressant action of diazepam upon secondary vestibular neurons.",

author = "Barmack, {Neal H.} and Pettorossi, {Vito E.}",

note = "Funding Information: *This resea.,~ was supported by N.I.H. Grant EY 00848 and by tl~e Oregon Lions Sight and Hinting Foundation. V.E.P. is the re ~pient of C.N.R.-N.A.T.O. Fellowship and Oregon Lions Sight and Hearing Foundation Fellowship, ** Present address: Institute of Human Physiology, C~tho\]~c U~r'.vc~ity, R~,me, Italy.",

year = "1980",

month = mar,

doi = "10.1016/0304-3940(80)90022-1",

language = "English (US)",

volume = "16",

pages = "339--344",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "3",

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T1 - The influence of diazepam on the activity of secondary vestibular neurons in the rabbit

AU - Barmack, Neal H.

AU - Pettorossi, Vito E.

N1 - Funding Information: *This resea.,~ was supported by N.I.H. Grant EY 00848 and by tl~e Oregon Lions Sight and Hinting Foundation. V.E.P. is the re ~pient of C.N.R.-N.A.T.O. Fellowship and Oregon Lions Sight and Hearing Foundation Fellowship, ** Present address: Institute of Human Physiology, C~tho\]~c U~r'.vc~ity, R~,me, Italy.

PY - 1980/3

Y1 - 1980/3

N2 - We have studied the influence of intravenously administered diazepam on the activity of single secondary vestibular neurons in unanesthetized, paralyzed rabbits evoked by sinusoidal angular accelerations about the vertical and longitudinal axes. Intravenous injections of diazepam (20-100 μg/kg) caused a decreased sensitivity of all secondary vestibular neurons which were tested. The reduction in sensitivity was sometimes preceded by a transient increase in excitability which lasted 10-40 sec. The duration of the decreased sensitivity to vestibular stimulation following intravenous injections of diazepam was dose-dependent, lasting 15-60 min. These data suggest that the diazepam-induced reduction of vestibuloocular reflexes is caused, at least in part, by the depressant action of diazepam upon secondary vestibular neurons.

AB - We have studied the influence of intravenously administered diazepam on the activity of single secondary vestibular neurons in unanesthetized, paralyzed rabbits evoked by sinusoidal angular accelerations about the vertical and longitudinal axes. Intravenous injections of diazepam (20-100 μg/kg) caused a decreased sensitivity of all secondary vestibular neurons which were tested. The reduction in sensitivity was sometimes preceded by a transient increase in excitability which lasted 10-40 sec. The duration of the decreased sensitivity to vestibular stimulation following intravenous injections of diazepam was dose-dependent, lasting 15-60 min. These data suggest that the diazepam-induced reduction of vestibuloocular reflexes is caused, at least in part, by the depressant action of diazepam upon secondary vestibular neurons.

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U2 - 10.1016/0304-3940(80)90022-1

DO - 10.1016/0304-3940(80)90022-1

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SN - 0304-3940

VL - 16

SP - 339

EP - 344

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

The influence of diazepam on the activity of secondary vestibular neurons in the rabbit

Abstract

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