The inflammatory sequelae of aortic balloon occlusion in hemorrhagic shock

Jonathan J. Morrison, James Ross, Nickolay P. Markov, Daniel J. Scott, Jerry R. Spencer, Todd E. Rasmussen

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Results: All animals were successfully induced into hemorrhagic shock without mortality. All groups responded to aortic occlusion with a rise in blood pressure above baseline values. IL-6, as measured (picogram per milliliter) at 8 h, was significantly elevated from baseline values in the 60-REBOA and 90-REBOA groups: 289 ± 258 versus 10 ± 5; P = 0.018 and 630 ± 348; P = 0.007, respectively. There was a trend toward greater vasopressor use (P = 0.183) and increased incidence of acute respiratory distress syndrome (P = 0.052) across the groups.

Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a hemorrhage control and resuscitative adjunct that has been demonstrated to improve central perfusion during hemorrhagic shock. The aim of this study was to characterize the systemic inflammatory response associated and cardiopulmonary sequelae with 30, 60, and 90 min of balloon occlusion and shock on the release of interleukin 6 (IL-6) and tumor necrosis factor alpha.

Materials and methods: Anesthetized female Yorkshire swine (Sus scrofa, weight 70-90 kg) underwent a 35% blood volume-controlled hemorrhage followed by thoracic aortic balloon occlusion of 30 (30-REBOA, n = 6), 60 (60-REBOA, n = 8), and 90 min (90-REBOA, n = 6). This was followed by resuscitation with whole blood and crystalloid over 6 h. Animals then underwent 48 h of critical care with sedation, fluid, and vasopressor support.

Conclusions: REBOA is a useful adjunct in supporting central perfusion during hemorrhagic shock; however, increasing occlusion time and shock results in a greater IL-6 release. Clinicians must anticipate inflammation-mediated organ failure in post-REBOA use patients.

Original languageEnglish (US)
Pages (from-to)423-431
Number of pages9
JournalJournal of Surgical Research
Volume191
Issue number2
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Fingerprint

Balloon Occlusion
Hemorrhagic Shock
Aorta
Interleukin-6
Shock
Perfusion
Hemorrhage
Sus scrofa
Adult Respiratory Distress Syndrome
Critical Care
Blood Volume
Resuscitation
Swine
Thorax
Tumor Necrosis Factor-alpha
Blood Pressure
Inflammation

Keywords

  • Hemorrhagic shock
  • REBOA Noncompressible torso hemorrhage
  • Resuscitation
  • Resuscitative endovascular balloon occlusion of the aorta

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

Cite this

Morrison, J. J., Ross, J., Markov, N. P., Scott, D. J., Spencer, J. R., & Rasmussen, T. E. (2014). The inflammatory sequelae of aortic balloon occlusion in hemorrhagic shock. Journal of Surgical Research, 191(2), 423-431. https://doi.org/10.1016/j.jss.2014.04.012

The inflammatory sequelae of aortic balloon occlusion in hemorrhagic shock. / Morrison, Jonathan J.; Ross, James; Markov, Nickolay P.; Scott, Daniel J.; Spencer, Jerry R.; Rasmussen, Todd E.

In: Journal of Surgical Research, Vol. 191, No. 2, 01.10.2014, p. 423-431.

Research output: Contribution to journalArticle

Morrison, JJ, Ross, J, Markov, NP, Scott, DJ, Spencer, JR & Rasmussen, TE 2014, 'The inflammatory sequelae of aortic balloon occlusion in hemorrhagic shock', Journal of Surgical Research, vol. 191, no. 2, pp. 423-431. https://doi.org/10.1016/j.jss.2014.04.012
Morrison, Jonathan J. ; Ross, James ; Markov, Nickolay P. ; Scott, Daniel J. ; Spencer, Jerry R. ; Rasmussen, Todd E. / The inflammatory sequelae of aortic balloon occlusion in hemorrhagic shock. In: Journal of Surgical Research. 2014 ; Vol. 191, No. 2. pp. 423-431.
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