The inflammatory component of Kaposi sarcoma

Liron Pantanowitz, Ashlee V. Moses, Bruce J. Dezube

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Kaposi sarcoma (KS) is intimately linked to several aspects of the host immune system. KS development is linked to immunodeficiency in several clinical-epidemiological settings. The development of KS at local inflammatory sites has also been documented. Inflammatory cells are almost always present within KS lesions. Depending upon the inflammatory milieu, KS lesions may progress or regress. Not surprisingly, iatrogenic manipulation of host immunity with drugs may provoke KS growth and/or flare. Given the close association between KS and the immune system, the etiologic agent Kaposi Sarcoma Herpesvirus has developed a variety of mechanisms to evade the host immune system, all of which have cleverly evolved to promote oncogenesis and viral persistence.

Original languageEnglish (US)
Pages (from-to)163-165
Number of pages3
JournalExperimental and Molecular Pathology
Volume87
Issue number2
DOIs
StatePublished - Oct 1 2009

Keywords

  • Dendritic cell
  • Granuloma
  • HHV8
  • Immunity
  • Inflammation
  • KSHV

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

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