The inflammatory component of Kaposi sarcoma

Liron Pantanowitz, Ashlee Moses, Bruce J. Dezube

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Kaposi sarcoma (KS) is intimately linked to several aspects of the host immune system. KS development is linked to immunodeficiency in several clinical-epidemiological settings. The development of KS at local inflammatory sites has also been documented. Inflammatory cells are almost always present within KS lesions. Depending upon the inflammatory milieu, KS lesions may progress or regress. Not surprisingly, iatrogenic manipulation of host immunity with drugs may provoke KS growth and/or flare. Given the close association between KS and the immune system, the etiologic agent Kaposi Sarcoma Herpesvirus has developed a variety of mechanisms to evade the host immune system, all of which have cleverly evolved to promote oncogenesis and viral persistence.

Original languageEnglish (US)
Pages (from-to)163-165
Number of pages3
JournalExperimental and Molecular Pathology
Volume87
Issue number2
DOIs
StatePublished - Oct 2009

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Kaposi's Sarcoma
Immune system
Immune System
Pharmaceutical Preparations
Herpesviridae
Immunity
Carcinogenesis
Growth

Keywords

  • Dendritic cell
  • Granuloma
  • HHV8
  • Immunity
  • Inflammation
  • KSHV

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

The inflammatory component of Kaposi sarcoma. / Pantanowitz, Liron; Moses, Ashlee; Dezube, Bruce J.

In: Experimental and Molecular Pathology, Vol. 87, No. 2, 10.2009, p. 163-165.

Research output: Contribution to journalArticle

Pantanowitz, Liron ; Moses, Ashlee ; Dezube, Bruce J. / The inflammatory component of Kaposi sarcoma. In: Experimental and Molecular Pathology. 2009 ; Vol. 87, No. 2. pp. 163-165.
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