The induction of oral ethanol self-administration by contingent ethanol delivery

Kathleen A. Grant, Herman H. Samson

    Research output: Contribution to journalArticle

    8 Scopus citations

    Abstract

    The necessity of delivering a highly reinforcing stimulus (20% sucrose) contingent upon ethanol consumption in order to induce ethanol self-administration in free-feeding rats was investigated. Rats water deprived for 12-16 h were placed in an environment in which ethanol drinking resulted in the presentation of ethanol. This procedure was successful in inducing and maintaining ethanol self-administration over concentrations of 5-20% (v/v). Compared to a group of rats initially reinforced for drinking ethanol with sucrose presentation, contingent ethanol delivery resulted in greater ethanol self-administration behavior. When 20% ethanol was available the group trained with ethanol had average intake of 0.91 g/kg, whereas the group trained with sucrose had a mean intake of 0.69 g/kg in a 30-min session. The results suggest that ethanol's reinforcing properties are sufficient to establish ethanol self-administration within the context of the inducing environment.

    Original languageEnglish (US)
    Pages (from-to)361-368
    Number of pages8
    JournalDrug and Alcohol Dependence
    Volume16
    Issue number4
    DOIs
    StatePublished - Feb 1986

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    Keywords

    • Alcohol
    • Alcohol self-administration
    • Rats
    • Reinforcement

    ASJC Scopus subject areas

    • Toxicology
    • Pharmacology
    • Psychiatry and Mental health
    • Pharmacology (medical)

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