The importance of the circadian system & sleep for bone health

Christine M. Swanson; Wendy M. Kohrt; Orfeu M. Buxton; Carol A. Everson; Kenneth P. Wright; Eric S. Orwoll; Steven A. Shea

doi:10.1016/j.metabol.2017.12.002

The importance of the circadian system & sleep for bone health

Christine M. Swanson, Wendy M. Kohrt, Orfeu M. Buxton, Carol A. Everson, Kenneth P. Wright, Eric S. Orwoll, Steven A. Shea

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.

Original language	English (US)
Pages (from-to)	28-43
Number of pages	16
Journal	Metabolism: Clinical and Experimental
Volume	84
DOIs	https://doi.org/10.1016/j.metabol.2017.12.002
State	Published - Jul 2018

Keywords

Bone
Bone turnover
Circadian
Fracture
Sleep

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.metabol.2017.12.002

Cite this

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title = "The importance of the circadian system & sleep for bone health",

abstract = "Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.",

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AU - Swanson, Christine M.

AU - Kohrt, Wendy M.

AU - Buxton, Orfeu M.

AU - Everson, Carol A.

AU - Wright, Kenneth P.

AU - Orwoll, Eric S.

AU - Shea, Steven A.

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AB - Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.

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KW - Circadian

KW - Fracture

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The importance of the circadian system & sleep for bone health

Abstract

Keywords

ASJC Scopus subject areas

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