The importance of the circadian system & sleep for bone health

Christine M. Swanson, Wendy M. Kohrt, Orfeu M. Buxton, Carol A. Everson, Kenneth P. Wright, Eric Orwoll, Steven Shea

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.

Original languageEnglish (US)
JournalMetabolism: Clinical and Experimental
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Sleep
Bone and Bones
Health
Biological Phenomena
Circadian Clocks
Bone Remodeling
Melatonin
Caffeine
Genes

Keywords

  • Bone
  • Bone turnover
  • Circadian
  • Fracture
  • Sleep

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The importance of the circadian system & sleep for bone health. / Swanson, Christine M.; Kohrt, Wendy M.; Buxton, Orfeu M.; Everson, Carol A.; Wright, Kenneth P.; Orwoll, Eric; Shea, Steven.

In: Metabolism: Clinical and Experimental, 01.01.2018.

Research output: Contribution to journalArticle

Swanson, Christine M. ; Kohrt, Wendy M. ; Buxton, Orfeu M. ; Everson, Carol A. ; Wright, Kenneth P. ; Orwoll, Eric ; Shea, Steven. / The importance of the circadian system & sleep for bone health. In: Metabolism: Clinical and Experimental. 2018.
@article{14d582dba9f5411896c2b9e59e5dce6e,
title = "The importance of the circadian system & sleep for bone health",
abstract = "Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.",
keywords = "Bone, Bone turnover, Circadian, Fracture, Sleep",
author = "Swanson, {Christine M.} and Kohrt, {Wendy M.} and Buxton, {Orfeu M.} and Everson, {Carol A.} and Wright, {Kenneth P.} and Eric Orwoll and Steven Shea",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.metabol.2017.12.002",
language = "English (US)",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - The importance of the circadian system & sleep for bone health

AU - Swanson, Christine M.

AU - Kohrt, Wendy M.

AU - Buxton, Orfeu M.

AU - Everson, Carol A.

AU - Wright, Kenneth P.

AU - Orwoll, Eric

AU - Shea, Steven

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.

AB - Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.

KW - Bone

KW - Bone turnover

KW - Circadian

KW - Fracture

KW - Sleep

UR - http://www.scopus.com/inward/record.url?scp=85040451185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040451185&partnerID=8YFLogxK

U2 - 10.1016/j.metabol.2017.12.002

DO - 10.1016/j.metabol.2017.12.002

M3 - Article

C2 - 29229227

AN - SCOPUS:85040451185

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

ER -