Abstract
Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.
| Original language | English (US) |
|---|---|
| Journal | Metabolism: Clinical and Experimental |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- Bone
- Bone turnover
- Circadian
- Fracture
- Sleep
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
The importance of the circadian system & sleep for bone health. / Swanson, Christine M.; Kohrt, Wendy M.; Buxton, Orfeu M.; Everson, Carol A.; Wright, Kenneth P.; Orwoll, Eric; Shea, Steven.
In: Metabolism: Clinical and Experimental, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The importance of the circadian system & sleep for bone health
AU - Swanson, Christine M.
AU - Kohrt, Wendy M.
AU - Buxton, Orfeu M.
AU - Everson, Carol A.
AU - Wright, Kenneth P.
AU - Orwoll, Eric
AU - Shea, Steven
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.
AB - Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.
KW - Bone
KW - Bone turnover
KW - Circadian
KW - Fracture
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=85040451185&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040451185&partnerID=8YFLogxK
U2 - 10.1016/j.metabol.2017.12.002
DO - 10.1016/j.metabol.2017.12.002
M3 - Article
C2 - 29229227
AN - SCOPUS:85040451185
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
ER -