The Importance of Placebo Effects in Pain Treatment and Research

Judith A. Turner, Richard (Rick) Deyo, John D. Loeser, Michael Von Korff, Wilbert E. Fordyce

Research output: Contribution to journalArticle

660 Citations (Scopus)

Abstract

To estimate the importance and implications of placebo effects in pain treatment and research from the existing literature, with emphasis on their magnitude and duration, the conditions influencing them, and proposed explanations. English-language articles and books identified through MEDLINE (1980 through 1993) and Psyc LIT (1967 through 1993) database searching, bibliography review, and expert consultation. Articles were included if they pertained to the review objectives. Placebo response rates vary greatly and are frequently much higher than the often-cited one third. Placebos have time-effect curves, and peak, cumulative, and carryover effects similar to those of active medications. As with medication, surgery can produce substantial placebo effects, and this possibility is commonly overlooked in case series reports on back surgery. Individuals are not consistent in their placebo responses, and a placebo-responder personality has not been identified. Models advanced to explain placebo effects emphasize the role of anxiety, expectations, and learning. Placebo effects influence patient outcomes after any treatment, including surgery, that the clinician and patient believe is effective. Placebo effects plus disease natural history and regression to the mean can result in high rates of good outcomes, which may be misattributed to specific treatment effects. The true causes of improvements in pain after treatment remain unknown in the absence of independently evaluated randomized controlled trials.

Original languageEnglish (US)
Pages (from-to)1609-1614
Number of pages6
JournalJAMA - Journal of the American Medical Association
Volume271
Issue number20
DOIs
StatePublished - May 25 1994
Externally publishedYes

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Placebo Effect
Pain
Placebos
Research
Therapeutics
Bibliography
Natural History
MEDLINE
Personality
Language
Referral and Consultation
Anxiety
Randomized Controlled Trials
Learning
Databases

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The Importance of Placebo Effects in Pain Treatment and Research. / Turner, Judith A.; Deyo, Richard (Rick); Loeser, John D.; Von Korff, Michael; Fordyce, Wilbert E.

In: JAMA - Journal of the American Medical Association, Vol. 271, No. 20, 25.05.1994, p. 1609-1614.

Research output: Contribution to journalArticle

Turner, Judith A. ; Deyo, Richard (Rick) ; Loeser, John D. ; Von Korff, Michael ; Fordyce, Wilbert E. / The Importance of Placebo Effects in Pain Treatment and Research. In: JAMA - Journal of the American Medical Association. 1994 ; Vol. 271, No. 20. pp. 1609-1614.
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