The importance of early surgical intervention for patients with active infective endocarditis

S. M. Langley, M. J R Dalrymple-Hay, H. Stafford, T. J. Edwards, S. A. Livesey, J. L. Monro

Research output: Contribution to journalArticle

Abstract

Background: The duration of medical treatment in a patient with infective endocarditis and timing of surgery can be a difficult clinical decision. This study was undertaken to determine whether specific preoperative variables were independent risk factors for operative mortality and establish long term prognosis for patients undergoing valvular surgery for endocarditis. Methods: Two hundred and seventeen consecutive patients with active infective endocarditis between 1972 and 1997 were studied. The 152 males (70%) and 65 females (30%) with mean age 53 (6-80) underwent a total of 227 valve replacements or repairs. Native valve endocarditis (NVE) was present in 162 (71%) and prosthetic valve endocarditis (PVE) in 65 (29%). The valve position infected was the aortic alone in 115 (51%), mitral alone in 71(31%), and others in 41 (18%). Results: The overall early (30 day) mortality was 9.7% ((21/217). For patients with NVE the early mortality was 8.0% (13/162) and for those with PVE 12.3% (8/65) (p=0.3). Preoperative risk factors for early mortality, as determined by multiple logistic regression analysis, included increased duration of antibiotic treatment prior to surgery, younger age and poor left ventricular function (p

Original languageEnglish (US)
JournalHeart
Volume81
Issue numberSUPPL. 1
StatePublished - May 1999
Externally publishedYes

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Endocarditis
Mortality
Left Ventricular Function
Logistic Models
Regression Analysis
Anti-Bacterial Agents
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Langley, S. M., Dalrymple-Hay, M. J. R., Stafford, H., Edwards, T. J., Livesey, S. A., & Monro, J. L. (1999). The importance of early surgical intervention for patients with active infective endocarditis. Heart, 81(SUPPL. 1).

The importance of early surgical intervention for patients with active infective endocarditis. / Langley, S. M.; Dalrymple-Hay, M. J R; Stafford, H.; Edwards, T. J.; Livesey, S. A.; Monro, J. L.

In: Heart, Vol. 81, No. SUPPL. 1, 05.1999.

Research output: Contribution to journalArticle

Langley, SM, Dalrymple-Hay, MJR, Stafford, H, Edwards, TJ, Livesey, SA & Monro, JL 1999, 'The importance of early surgical intervention for patients with active infective endocarditis', Heart, vol. 81, no. SUPPL. 1.
Langley SM, Dalrymple-Hay MJR, Stafford H, Edwards TJ, Livesey SA, Monro JL. The importance of early surgical intervention for patients with active infective endocarditis. Heart. 1999 May;81(SUPPL. 1).
Langley, S. M. ; Dalrymple-Hay, M. J R ; Stafford, H. ; Edwards, T. J. ; Livesey, S. A. ; Monro, J. L. / The importance of early surgical intervention for patients with active infective endocarditis. In: Heart. 1999 ; Vol. 81, No. SUPPL. 1.
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