The impact of short stature on health-related quality of life in children with chronic kidney disease

Amira Al-Uzri, Matthew Matheson, Debbie S. Gipson, Susan R. Mendley, Stephen R. Hooper, Ora Yadin, David Rozansky, Marva Moxey-Mims, Susan L. Furth, Bradley A. Warady, Arlene C. Gerson

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objectives: To compare the health-related quality of life (HRQoL) of children with chronic kidney disease (CKD) and short stature (SS) with that of children with CKD and normal height (NH), to evaluate the impact of catch-up growth and growth hormone (GH) use on HRQoL, and to describe the concordance of perceptions of HRQoL between children with SS and NH and their parents. Study design: Four hundred eighty-three children and/or parents enrolled in the multicenter Chronic Kidney Disease in Children study who had completed the Pediatric Quality of Life Inventory (Version 4.0) on at least 2 Chronic Kidney Disease in Children study visits composed this substudy population. Participants were dichotomized into NH or SS groups. The demographic characteristics that varied at baseline (sex, glomerular filtration rate, and parent education) were controlled for in the main analysis evaluating the impact of catch-up growth and use of GH on HRQoL. Results: Multivariate modeling (controlling for confounding variables) revealed a significant association between both catch-up growth and GH use on parent-proxy reports of child physical functioning (P

Original languageEnglish (US)
JournalJournal of Pediatrics
Volume163
Issue number3
DOIs
StatePublished - Sep 2013

Fingerprint

Chronic Renal Insufficiency
Quality of Life
Growth Hormone
Growth
Parents
Confounding Factors (Epidemiology)
Proxy
Glomerular Filtration Rate
Demography
Pediatrics
Education
Equipment and Supplies
Population

Keywords

  • Chronic kidney disease
  • Chronic Kidney Disease in Children
  • CKD
  • CKiD
  • eGFR
  • Estimated glomerular filtration rate
  • GH
  • Growth hormone
  • Health-related quality of life
  • HRQoL
  • ieGFR
  • iGFR
  • Iohexol-based glomerular filtration rate
  • Maternal education
  • ME
  • NH
  • Normal height
  • Pediatric Quality of Life Inventory
  • PedsQL
  • Reflects the use of iGFR if it is available, eGFR if it is not
  • Short stature
  • SS

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The impact of short stature on health-related quality of life in children with chronic kidney disease. / Al-Uzri, Amira; Matheson, Matthew; Gipson, Debbie S.; Mendley, Susan R.; Hooper, Stephen R.; Yadin, Ora; Rozansky, David; Moxey-Mims, Marva; Furth, Susan L.; Warady, Bradley A.; Gerson, Arlene C.

In: Journal of Pediatrics, Vol. 163, No. 3, 09.2013.

Research output: Contribution to journalArticle

Al-Uzri, A, Matheson, M, Gipson, DS, Mendley, SR, Hooper, SR, Yadin, O, Rozansky, D, Moxey-Mims, M, Furth, SL, Warady, BA & Gerson, AC 2013, 'The impact of short stature on health-related quality of life in children with chronic kidney disease', Journal of Pediatrics, vol. 163, no. 3. https://doi.org/10.1016/j.jpeds.2013.03.016
Al-Uzri, Amira ; Matheson, Matthew ; Gipson, Debbie S. ; Mendley, Susan R. ; Hooper, Stephen R. ; Yadin, Ora ; Rozansky, David ; Moxey-Mims, Marva ; Furth, Susan L. ; Warady, Bradley A. ; Gerson, Arlene C. / The impact of short stature on health-related quality of life in children with chronic kidney disease. In: Journal of Pediatrics. 2013 ; Vol. 163, No. 3.
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