The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators

Ahmed A. Ismail, Kai Wang, James R. Olson, Matthew R. Bonner, Olfat Hendy, Gaafar Abdel Rasoul, Diane Rohlman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Egyptian adolescents are hired as seasonal workers to apply pesticides to the cotton crop and may perform this occupation for several years. However, few studies examined the effects of repeated pesticide exposure on health outcomes The goal of this study was to determine the impact of repeated pesticide exposure on neurobehavioral (NB) performance and biomarkers of exposure (urinary metabolite) and effect (cholinesterase activity). Eighty-four adolescents from two field stations in Menoufia, Egypt, were examined four times: before and during pesticide application season in 2010 and again before and during application season in 2011. At each of the four time points, participants completed a questionnaire, performed an NB test battery, and were assessed for urinary levels of the chlorpyrifos metabolite TCPy (3,5,6-trichloro-2-pyridinol) and blood cholinesterase activity. Following the study cohort over two consecutive pesticide application seasons revealed that TCPy levels significantly increased following exposure, and returned to baseline levels following the end of the application season. Blood butyryl cholinesterase activity exhibited a similar pattern. Although NB outcomes displayed learning and practice effects over time, deficits in performance were significantly associated with increased TCPy levels with reduction in the number of NB measures showing improvement over time. Biomarkers of exposure and effect demonstrated changes associated with pesticide application and recovery after application ended. Deficits in NB performance were correlated with elevated pesticide exposure. Data demonstrated that repeated pesticide exposure may exert a long-term adverse impact on human health.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
DOIs
StateAccepted/In press - Sep 8 2017
Externally publishedYes

Fingerprint

Applicators
Biomarkers
Pesticides
Cholinesterases
Metabolites
Blood
Health
Chlorpyrifos
Egypt
Occupations
Cotton
Crops
Cohort Studies
Learning
Recovery

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators. / Ismail, Ahmed A.; Wang, Kai; Olson, James R.; Bonner, Matthew R.; Hendy, Olfat; Rasoul, Gaafar Abdel; Rohlman, Diane.

In: Journal of Toxicology and Environmental Health - Part A: Current Issues, 08.09.2017, p. 1-13.

Research output: Contribution to journalArticle

Ismail, Ahmed A. ; Wang, Kai ; Olson, James R. ; Bonner, Matthew R. ; Hendy, Olfat ; Rasoul, Gaafar Abdel ; Rohlman, Diane. / The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators. In: Journal of Toxicology and Environmental Health - Part A: Current Issues. 2017 ; pp. 1-13.
@article{0169addc263840cfa4ff8503fa640566,
title = "The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators",
abstract = "Egyptian adolescents are hired as seasonal workers to apply pesticides to the cotton crop and may perform this occupation for several years. However, few studies examined the effects of repeated pesticide exposure on health outcomes The goal of this study was to determine the impact of repeated pesticide exposure on neurobehavioral (NB) performance and biomarkers of exposure (urinary metabolite) and effect (cholinesterase activity). Eighty-four adolescents from two field stations in Menoufia, Egypt, were examined four times: before and during pesticide application season in 2010 and again before and during application season in 2011. At each of the four time points, participants completed a questionnaire, performed an NB test battery, and were assessed for urinary levels of the chlorpyrifos metabolite TCPy (3,5,6-trichloro-2-pyridinol) and blood cholinesterase activity. Following the study cohort over two consecutive pesticide application seasons revealed that TCPy levels significantly increased following exposure, and returned to baseline levels following the end of the application season. Blood butyryl cholinesterase activity exhibited a similar pattern. Although NB outcomes displayed learning and practice effects over time, deficits in performance were significantly associated with increased TCPy levels with reduction in the number of NB measures showing improvement over time. Biomarkers of exposure and effect demonstrated changes associated with pesticide application and recovery after application ended. Deficits in NB performance were correlated with elevated pesticide exposure. Data demonstrated that repeated pesticide exposure may exert a long-term adverse impact on human health.",
author = "Ismail, {Ahmed A.} and Kai Wang and Olson, {James R.} and Bonner, {Matthew R.} and Olfat Hendy and Rasoul, {Gaafar Abdel} and Diane Rohlman",
year = "2017",
month = "9",
day = "8",
doi = "10.1080/15287394.2017.1362612",
language = "English (US)",
pages = "1--13",
journal = "Journal of Toxicology and Environmental Health - Part A: Current Issues",
issn = "0098-4108",
publisher = "Taylor and Francis Ltd.",

}

TY - JOUR

T1 - The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators

AU - Ismail, Ahmed A.

AU - Wang, Kai

AU - Olson, James R.

AU - Bonner, Matthew R.

AU - Hendy, Olfat

AU - Rasoul, Gaafar Abdel

AU - Rohlman, Diane

PY - 2017/9/8

Y1 - 2017/9/8

N2 - Egyptian adolescents are hired as seasonal workers to apply pesticides to the cotton crop and may perform this occupation for several years. However, few studies examined the effects of repeated pesticide exposure on health outcomes The goal of this study was to determine the impact of repeated pesticide exposure on neurobehavioral (NB) performance and biomarkers of exposure (urinary metabolite) and effect (cholinesterase activity). Eighty-four adolescents from two field stations in Menoufia, Egypt, were examined four times: before and during pesticide application season in 2010 and again before and during application season in 2011. At each of the four time points, participants completed a questionnaire, performed an NB test battery, and were assessed for urinary levels of the chlorpyrifos metabolite TCPy (3,5,6-trichloro-2-pyridinol) and blood cholinesterase activity. Following the study cohort over two consecutive pesticide application seasons revealed that TCPy levels significantly increased following exposure, and returned to baseline levels following the end of the application season. Blood butyryl cholinesterase activity exhibited a similar pattern. Although NB outcomes displayed learning and practice effects over time, deficits in performance were significantly associated with increased TCPy levels with reduction in the number of NB measures showing improvement over time. Biomarkers of exposure and effect demonstrated changes associated with pesticide application and recovery after application ended. Deficits in NB performance were correlated with elevated pesticide exposure. Data demonstrated that repeated pesticide exposure may exert a long-term adverse impact on human health.

AB - Egyptian adolescents are hired as seasonal workers to apply pesticides to the cotton crop and may perform this occupation for several years. However, few studies examined the effects of repeated pesticide exposure on health outcomes The goal of this study was to determine the impact of repeated pesticide exposure on neurobehavioral (NB) performance and biomarkers of exposure (urinary metabolite) and effect (cholinesterase activity). Eighty-four adolescents from two field stations in Menoufia, Egypt, were examined four times: before and during pesticide application season in 2010 and again before and during application season in 2011. At each of the four time points, participants completed a questionnaire, performed an NB test battery, and were assessed for urinary levels of the chlorpyrifos metabolite TCPy (3,5,6-trichloro-2-pyridinol) and blood cholinesterase activity. Following the study cohort over two consecutive pesticide application seasons revealed that TCPy levels significantly increased following exposure, and returned to baseline levels following the end of the application season. Blood butyryl cholinesterase activity exhibited a similar pattern. Although NB outcomes displayed learning and practice effects over time, deficits in performance were significantly associated with increased TCPy levels with reduction in the number of NB measures showing improvement over time. Biomarkers of exposure and effect demonstrated changes associated with pesticide application and recovery after application ended. Deficits in NB performance were correlated with elevated pesticide exposure. Data demonstrated that repeated pesticide exposure may exert a long-term adverse impact on human health.

UR - http://www.scopus.com/inward/record.url?scp=85029408744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029408744&partnerID=8YFLogxK

U2 - 10.1080/15287394.2017.1362612

DO - 10.1080/15287394.2017.1362612

M3 - Article

SP - 1

EP - 13

JO - Journal of Toxicology and Environmental Health - Part A: Current Issues

JF - Journal of Toxicology and Environmental Health - Part A: Current Issues

SN - 0098-4108

ER -