The impact of genetic research on our understanding of Parkinson's disease

Ian Martin, Valina L. Dawson, Ted M. Dawson

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations

Abstract

Until recently, genetics was thought to play a minor role in the development of Parkinson's disease (PD). Over the last decade, a number of genes that definitively cause PD have been identified, which has led to the generation of disease models based on pathogenic gene variants that recapitulate many features of the disease. These genetic studies have provided novel insight into potential mechanisms underlying the aetiology of PD. This chapter will provide a profile of the genes conclusively linked to PD and will outline the mechanisms of PD pathogenesis implicated by genetic studies. Mitochondrial dysfunction, oxidative stress and impaired ubiquitin-proteasome system function are disease mechanisms that are particularly well supported by genetic studies and are therefore the focus of this chapter.

Original languageEnglish (US)
Title of host publicationProgress in Brain Research
PublisherElsevier B.V.
Pages21-41
Number of pages21
EditionC
DOIs
StatePublished - Jan 1 2010

Publication series

NameProgress in Brain Research
NumberC
Volume183
ISSN (Print)0079-6123

Keywords

  • Alpha-synuclein
  • DJ-1
  • LRRK2
  • Mitochondrial dysfunction
  • Oxidative stress
  • Parkin
  • PINK1
  • Ubiquitin-proteasome system

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Martin, I., Dawson, V. L., & Dawson, T. M. (2010). The impact of genetic research on our understanding of Parkinson's disease. In Progress in Brain Research (C ed., pp. 21-41). (Progress in Brain Research; Vol. 183, No. C). Elsevier B.V.. https://doi.org/10.1016/S0079-6123(10)83002-X