The impact of genetic research on our understanding of Parkinson's disease

Ian Martin, Valina L. Dawson, Ted M. Dawson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Until recently, genetics was thought to play a minor role in the development of Parkinson's disease (PD). Over the last decade, a number of genes that definitively cause PD have been identified, which has led to the generation of disease models based on pathogenic gene variants that recapitulate many features of the disease. These genetic studies have provided novel insight into potential mechanisms underlying the aetiology of PD. This chapter will provide a profile of the genes conclusively linked to PD and will outline the mechanisms of PD pathogenesis implicated by genetic studies. Mitochondrial dysfunction, oxidative stress and impaired ubiquitin-proteasome system function are disease mechanisms that are particularly well supported by genetic studies and are therefore the focus of this chapter.

Original languageEnglish (US)
Pages (from-to)21-41
Number of pages21
JournalProgress in Brain Research
Volume183
Issue numberC
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Genetic Research
Parkinson Disease
Genes
Proteasome Endopeptidase Complex
Ubiquitin
Oxidative Stress

Keywords

  • Alpha-synuclein
  • DJ-1
  • LRRK2
  • Mitochondrial dysfunction
  • Oxidative stress
  • Parkin
  • PINK1
  • Ubiquitin-proteasome system

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The impact of genetic research on our understanding of Parkinson's disease. / Martin, Ian; Dawson, Valina L.; Dawson, Ted M.

In: Progress in Brain Research, Vol. 183, No. C, 2010, p. 21-41.

Research output: Contribution to journalArticle

Martin, Ian ; Dawson, Valina L. ; Dawson, Ted M. / The impact of genetic research on our understanding of Parkinson's disease. In: Progress in Brain Research. 2010 ; Vol. 183, No. C. pp. 21-41.
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