The immune response to CMV infection and vaccination in mice, monkeys and humans: recent developments

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The immune response to CMV is characterized by extremely large T cell and antibody responses that persist for a lifetime, but do not prevent superinfection with other CMV strains. This makes generation of a vaccine against CMV very difficult, but has facilitated development of CMV-vectored vaccines, which have shown promise in mouse tumor models and in monkey models of infectious disease. The serendipitous use of a mutant rhesus CMV vector for the SIV vaccine elicited extraordinary, CD8 T cell responses restricted by MHCII and non-classical MHCI molecules which apparently provide protection against SIV. CMV-specific CD8 T cell responses in the mouse model are driven by antigen and live out their lives primarily within the intravascular compartment.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalCurrent Opinion in Virology
Volume28
DOIs
StatePublished - Feb 1 2018

Fingerprint

Human Development
Haplorhini
Vaccination
T-Lymphocytes
SAIDS Vaccines
Vaccines
Infection
Superinfection
Antibody Formation
Communicable Diseases
Antigens
Neoplasms

ASJC Scopus subject areas

  • Virology

Cite this

The immune response to CMV infection and vaccination in mice, monkeys and humans : recent developments. / Hill, Ann.

In: Current Opinion in Virology, Vol. 28, 01.02.2018, p. 161-166.

Research output: Contribution to journalReview article

@article{6d2c0dcd3ab24c0e8316c26ba2d1e5e6,
title = "The immune response to CMV infection and vaccination in mice, monkeys and humans: recent developments",
abstract = "The immune response to CMV is characterized by extremely large T cell and antibody responses that persist for a lifetime, but do not prevent superinfection with other CMV strains. This makes generation of a vaccine against CMV very difficult, but has facilitated development of CMV-vectored vaccines, which have shown promise in mouse tumor models and in monkey models of infectious disease. The serendipitous use of a mutant rhesus CMV vector for the SIV vaccine elicited extraordinary, CD8 T cell responses restricted by MHCII and non-classical MHCI molecules which apparently provide protection against SIV. CMV-specific CD8 T cell responses in the mouse model are driven by antigen and live out their lives primarily within the intravascular compartment.",
author = "Ann Hill",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.coviro.2018.01.006",
language = "English (US)",
volume = "28",
pages = "161--166",
journal = "Current Opinion in Virology",
issn = "1879-6257",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - The immune response to CMV infection and vaccination in mice, monkeys and humans

T2 - recent developments

AU - Hill, Ann

PY - 2018/2/1

Y1 - 2018/2/1

N2 - The immune response to CMV is characterized by extremely large T cell and antibody responses that persist for a lifetime, but do not prevent superinfection with other CMV strains. This makes generation of a vaccine against CMV very difficult, but has facilitated development of CMV-vectored vaccines, which have shown promise in mouse tumor models and in monkey models of infectious disease. The serendipitous use of a mutant rhesus CMV vector for the SIV vaccine elicited extraordinary, CD8 T cell responses restricted by MHCII and non-classical MHCI molecules which apparently provide protection against SIV. CMV-specific CD8 T cell responses in the mouse model are driven by antigen and live out their lives primarily within the intravascular compartment.

AB - The immune response to CMV is characterized by extremely large T cell and antibody responses that persist for a lifetime, but do not prevent superinfection with other CMV strains. This makes generation of a vaccine against CMV very difficult, but has facilitated development of CMV-vectored vaccines, which have shown promise in mouse tumor models and in monkey models of infectious disease. The serendipitous use of a mutant rhesus CMV vector for the SIV vaccine elicited extraordinary, CD8 T cell responses restricted by MHCII and non-classical MHCI molecules which apparently provide protection against SIV. CMV-specific CD8 T cell responses in the mouse model are driven by antigen and live out their lives primarily within the intravascular compartment.

UR - http://www.scopus.com/inward/record.url?scp=85042226026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042226026&partnerID=8YFLogxK

U2 - 10.1016/j.coviro.2018.01.006

DO - 10.1016/j.coviro.2018.01.006

M3 - Review article

C2 - 29459261

AN - SCOPUS:85042226026

VL - 28

SP - 161

EP - 166

JO - Current Opinion in Virology

JF - Current Opinion in Virology

SN - 1879-6257

ER -