Abstract
The immune response to CMV is characterized by extremely large T cell and antibody responses that persist for a lifetime, but do not prevent superinfection with other CMV strains. This makes generation of a vaccine against CMV very difficult, but has facilitated development of CMV-vectored vaccines, which have shown promise in mouse tumor models and in monkey models of infectious disease. The serendipitous use of a mutant rhesus CMV vector for the SIV vaccine elicited extraordinary, CD8 T cell responses restricted by MHCII and non-classical MHCI molecules which apparently provide protection against SIV. CMV-specific CD8 T cell responses in the mouse model are driven by antigen and live out their lives primarily within the intravascular compartment.
Original language | English (US) |
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Pages (from-to) | 161-166 |
Number of pages | 6 |
Journal | Current Opinion in Virology |
Volume | 28 |
DOIs | |
State | Published - Feb 2018 |
ASJC Scopus subject areas
- Virology