The hypothalamic path to obesity

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Obesity is a growing public health concern, affecting an estimated 11% of children in Western society. The impact of obesity-related morbidity and mortality on society is significant, with both genetic and environmental factors contributing to its development. In most individuals, food intake and energy expenditure are tightly regulated by a feedback system comprising a number of hormonal and central nervous system pathways. Leptin released from adipocytes acts on hypothalamic neurons to release proopiomelanocortin (POMC), leading to a cascade of neuronal and hormonal events that inhibit feeding behavior. Specific gene mutations in the leptin/POMC pathways account for only 5% of all cases of obesity, and most cases of familial or idiopathic obesity are polygenic in origin. Although further research to identify specific genetic causes of obesity may lead to more tailored therapies, significant changes in societal and individual behavior are needed to stop the obesity epidemic from progressing.

Original languageEnglish (US)
Pages (from-to)1289-1295
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume17
Issue numberSUPPL. 4
StatePublished - 2004

Fingerprint

Obesity
Pro-Opiomelanocortin
Leptin
Feeding Behavior
Adipocytes
Energy Metabolism
Central Nervous System
Public Health
Eating
Morbidity
Neurons
Mutation
Mortality
Research
Genes
Therapeutics

Keywords

  • Agouti-related peptide
  • Ghrelin
  • Leptin
  • Melanocortin-4 receptor
  • Neuropeptide Y
  • Obesity
  • Prohormone convertase
  • Proopiomelanocortin
  • Weight set point

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

Cite this

The hypothalamic path to obesity. / Boston, Bruce.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 17, No. SUPPL. 4, 2004, p. 1289-1295.

Research output: Contribution to journalArticle

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