The human papillomavirus infection in men study: Human papillomavirus prevalence and type distribution among men residing in Brazil, Mexico, and the United States

Anna R. Giuliano, Eduardo Lazcano-Ponce, Luisa L. Villa, Roberto Flores, Jorge Salmeron, Ji Hyun Lee, Mary R. Papenfuss, Martha Abrahamsen, Emily Jolles, Carrie M. Nielson, Maria Luisa Baggio, Roberto Silva, Manuel Quiterio

Research output: Contribution to journalArticle

216 Scopus citations

Abstract

Male sexual behavior influences the rates of cervical dysplasia and invasive cervical cancer, as well as male human papillomavirus (HPV) infection and disease. Unfortunately, little is known regarding male HPV type distribution by age and across countries. In samples combined from the coronal sulcus, glans penis, shaft, and scrotum of 1,160 men from Brazil, Mexico, and the United States, overall HPV prevalence was 65.2%, with 12.0% oncogenic types only, 20.7% nononcogenic types only, 17.8% both oncogenic and nononcogenic, and 14.7% unclassified infections. Multiple HPV types were detected in 25.7% of study participants. HPV prevalence was higher in Brazil (72.3%) than in the United States (61.3%) and Mexico (61.9%). HPV16 (6.5%), HPV51 (5.3%), and HPV59 (5.3%) were the most commonly detected oncogenic infections, and HPV84 (7.7%), HPV62 (7.3%), and HPV6 (6.6%) were the most commonly detected nononcogenic infections. Overall HPV prevalence was not associated with age. However, significant associations with age were observed when specific categories of HPV, nononcogenic, and unclassified HPV infections were considered. Studies of HPV type distribution among a broad age range of men from multiple countries is needed to fill the information gap internationally with respect to our knowledge of HPV infection in men.

Original languageEnglish (US)
Pages (from-to)2036-2043
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume17
Issue number8
DOIs
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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    Giuliano, A. R., Lazcano-Ponce, E., Villa, L. L., Flores, R., Salmeron, J., Lee, J. H., Papenfuss, M. R., Abrahamsen, M., Jolles, E., Nielson, C. M., Baggio, M. L., Silva, R., & Quiterio, M. (2008). The human papillomavirus infection in men study: Human papillomavirus prevalence and type distribution among men residing in Brazil, Mexico, and the United States. Cancer Epidemiology Biomarkers and Prevention, 17(8), 2036-2043. https://doi.org/10.1158/1055-9965.EPI-08-0151