The human gene for the β subunit of nerve growth factor is located on the proximal short arm of chromosome 1

Uta Francke, Bérengére De Martinville, Lisa Coussens, Axel Ullrich

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Fragments of the recently cloned human gene for the β subunit of nerve growth factor (β-NGF) were used as hybridization probes in analyzing two sets of rodent-human somatic cell hybrids for the presence of human β-NGF sequences. Results from the first set of hybrids assigned the human β-NGF gene to chromosome 1 and ruled out the presence of sequences of comparable homology on any other chromosome. With the second set of hybrids, which contained seven different, but overlapping, regions of chromosome 1, the NGF locus was mapped to band 1p22.

Original languageEnglish (US)
Pages (from-to)1248-1251
Number of pages4
JournalScience
Volume222
Issue number4629
StatePublished - 1983
Externally publishedYes

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Chromosomes, Human, Pair 1
Nerve Growth Factor
Genes
Hybrid Cells
Sequence Homology
Rodentia
Chromosomes

ASJC Scopus subject areas

  • General

Cite this

The human gene for the β subunit of nerve growth factor is located on the proximal short arm of chromosome 1. / Francke, Uta; De Martinville, Bérengére; Coussens, Lisa; Ullrich, Axel.

In: Science, Vol. 222, No. 4629, 1983, p. 1248-1251.

Research output: Contribution to journalArticle

Francke, U, De Martinville, B, Coussens, L & Ullrich, A 1983, 'The human gene for the β subunit of nerve growth factor is located on the proximal short arm of chromosome 1', Science, vol. 222, no. 4629, pp. 1248-1251.
Francke, Uta ; De Martinville, Bérengére ; Coussens, Lisa ; Ullrich, Axel. / The human gene for the β subunit of nerve growth factor is located on the proximal short arm of chromosome 1. In: Science. 1983 ; Vol. 222, No. 4629. pp. 1248-1251.
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