TY - JOUR
T1 - The human brain resonance of choline-containing compounds is similar in patients receiving lithium treatment and controls
T2 - An in vivo proton magnetic resonance spectroscopy study
AU - Stoll, Andrew L.
AU - Renshaw, Perry F.
AU - Sachs, Gary S.
AU - Guimaraes, Alexander R.
AU - Miller, Craig
AU - Cohen, Bruce M.
AU - Lafer, Beny
AU - Gonzalez, R. Gilberto
N1 - Funding Information:
This research was supported in part by Harvard Medical School Ethel Dupont-Warren (ALS) and Psychiatric Neuroscience Fellowships (ALS and PFR), and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil (BL), Eskalith CR was provided by NOVA Pharmaceutical Corp., Baltimore, MD.
PY - 1992/11/15
Y1 - 1992/11/15
N2 - Lithium specifically and potentially inhibits membrane transport of choline. However, the effect of lithium on human neuronal choline content is unknown. This study was performed to determine if lithium alters the human brain choline concentration in vivo. In vivo proton magnetic resonance spectroscopy was used to compare the relative brain concentration of choline-containing compounds in seven lithium-treated patients and six lithium-free controls. No significant difference was observed in the mean relative choline resonance between the patient and control groups. Lithium treatment did not appear to alter the overall brain content of choline-containing compounds. It remains possible that a component of these compounds, particularly free choline, is elevated during lithium treatment.
AB - Lithium specifically and potentially inhibits membrane transport of choline. However, the effect of lithium on human neuronal choline content is unknown. This study was performed to determine if lithium alters the human brain choline concentration in vivo. In vivo proton magnetic resonance spectroscopy was used to compare the relative brain concentration of choline-containing compounds in seven lithium-treated patients and six lithium-free controls. No significant difference was observed in the mean relative choline resonance between the patient and control groups. Lithium treatment did not appear to alter the overall brain content of choline-containing compounds. It remains possible that a component of these compounds, particularly free choline, is elevated during lithium treatment.
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U2 - 10.1016/0006-3223(92)90184-2
DO - 10.1016/0006-3223(92)90184-2
M3 - Article
C2 - 1467379
AN - SCOPUS:0027064950
SN - 0006-3223
VL - 32
SP - 944
EP - 949
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 10
ER -