The human brain resonance of choline-containing compounds is similar in patients receiving lithium treatment and controls: An in vivo proton magnetic resonance spectroscopy study

Andrew L. Stoll, Perry F. Renshaw, Gary S. Sachs, Alexander Guimaraes, Craig Miller, Bruce M. Cohen, Beny Lafer, R. Gilberto Gonzalez

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Lithium specifically and potentially inhibits membrane transport of choline. However, the effect of lithium on human neuronal choline content is unknown. This study was performed to determine if lithium alters the human brain choline concentration in vivo. In vivo proton magnetic resonance spectroscopy was used to compare the relative brain concentration of choline-containing compounds in seven lithium-treated patients and six lithium-free controls. No significant difference was observed in the mean relative choline resonance between the patient and control groups. Lithium treatment did not appear to alter the overall brain content of choline-containing compounds. It remains possible that a component of these compounds, particularly free choline, is elevated during lithium treatment.

Original languageEnglish (US)
Pages (from-to)944-949
Number of pages6
JournalBiological Psychiatry
Volume32
Issue number10
DOIs
StatePublished - Nov 15 1992
Externally publishedYes

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Choline
Lithium
Brain
Therapeutics
Proton Magnetic Resonance Spectroscopy
Control Groups
Membranes

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

The human brain resonance of choline-containing compounds is similar in patients receiving lithium treatment and controls : An in vivo proton magnetic resonance spectroscopy study. / Stoll, Andrew L.; Renshaw, Perry F.; Sachs, Gary S.; Guimaraes, Alexander; Miller, Craig; Cohen, Bruce M.; Lafer, Beny; Gonzalez, R. Gilberto.

In: Biological Psychiatry, Vol. 32, No. 10, 15.11.1992, p. 944-949.

Research output: Contribution to journalArticle

Stoll, Andrew L. ; Renshaw, Perry F. ; Sachs, Gary S. ; Guimaraes, Alexander ; Miller, Craig ; Cohen, Bruce M. ; Lafer, Beny ; Gonzalez, R. Gilberto. / The human brain resonance of choline-containing compounds is similar in patients receiving lithium treatment and controls : An in vivo proton magnetic resonance spectroscopy study. In: Biological Psychiatry. 1992 ; Vol. 32, No. 10. pp. 944-949.
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