The hippocampal formation participates in novel picture encoding: Evidence from functional magnetic resonance imaging

Chantal E. Stern, Suzanne Corkin, R. Gilberto González, Alexander Guimaraes, John R. Baker, Peggy J. Jennings, Cindy A. Carr, Robert M. Sugiura, Vasanth Vedantham, Bruce R. Rosen

Research output: Contribution to journalArticle

556 Scopus citations


Considerable evidence exists to support the hypothesis that the hippocampus and related medial temporal lobe structures are crucial for the encoding and storage of information in long-term memory. Few human imaging studies, however, have successfully shown signal intensity changes in these areas during encoding or retrieval. Using functional magnetic resonance imaging (fMRI), we studied normal human subjects while they performed a novel picture encoding task. High-speed echo-planar imaging techniques evaluated fMRI signal changes throughout the brain. During the encoding of novel pictures, statistically significant increases in fMRI signal were observed bilaterally in the posterior hippocampal formation and parahippocampal gyrus and in the lingual and fusiform gyri. To our knowledge, this experiment is the first fMRI study to show robust signal changes in the human hippocampal region. It also provides evidence that the encoding of novel, complex pictures depends upon an interaction between ventral cortical regions, specialized for object vision, and the hippocampal formation and parahippocampal gyrus, specialized for long-term memory.

Original languageEnglish (US)
Pages (from-to)8660-8665
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number16
Publication statusPublished - Aug 6 1996
Externally publishedYes


ASJC Scopus subject areas

  • Genetics
  • General

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