The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis

Daniel D. MacDougall, Zesen Lin, Nara L. Chon, Skyler Jackman, Hai Lin, Jefferson D. Knight, Arun Anantharam

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Synaptotagmin (Syt) proteins comprise a 17-member family, many of which trigger exocytosis in response to calcium. Historically, most studies have focused on the isoform Syt-1, which serves as the primary calcium sensor in synchronous neurotransmitter release. Recently, Syt-7 has become a topic of broad interest because of its extreme calcium sensitivity and diversity of roles in a wide range of cell types. Here, we review the known and emerging roles of Syt-7 in various contexts and stress the importance of its actions. Unique functions of Syt-7 are discussed in light of recent imaging, electrophysiological, and computational studies. Particular emphasis is placed on Syt-7-dependent regulation of synaptic transmission and neuroendocrine cell secretion. Finally, based on biochemical and structural data, we propose a mechanism to link Syt-7's role in membrane fusion with its role in subsequent fusion pore expansion via strong calcium-dependent phospholipid binding.

Original languageEnglish (US)
Pages (from-to)783-807
Number of pages25
JournalJournal of General Physiology
Volume150
Issue number6
DOIs
StatePublished - Jun 1 2018

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Synaptotagmins
Exocytosis
Calcium
Synaptotagmin I
Neuroendocrine Cells
Membrane Fusion
Synaptic Transmission
Neurotransmitter Agents
Phospholipids
Protein Isoforms

ASJC Scopus subject areas

  • Physiology

Cite this

The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis. / MacDougall, Daniel D.; Lin, Zesen; Chon, Nara L.; Jackman, Skyler; Lin, Hai; Knight, Jefferson D.; Anantharam, Arun.

In: Journal of General Physiology, Vol. 150, No. 6, 01.06.2018, p. 783-807.

Research output: Contribution to journalReview article

MacDougall, Daniel D. ; Lin, Zesen ; Chon, Nara L. ; Jackman, Skyler ; Lin, Hai ; Knight, Jefferson D. ; Anantharam, Arun. / The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis. In: Journal of General Physiology. 2018 ; Vol. 150, No. 6. pp. 783-807.
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