The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis

Daniel D. MacDougall, Zesen Lin, Nara L. Chon, Skyler L. Jackman, Hai Lin, Jefferson D. Knight, Arun Anantharam

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Synaptotagmin (Syt) proteins comprise a 17-member family, many of which trigger exocytosis in response to calcium. Historically, most studies have focused on the isoform Syt-1, which serves as the primary calcium sensor in synchronous neurotransmitter release. Recently, Syt-7 has become a topic of broad interest because of its extreme calcium sensitivity and diversity of roles in a wide range of cell types. Here, we review the known and emerging roles of Syt-7 in various contexts and stress the importance of its actions. Unique functions of Syt-7 are discussed in light of recent imaging, electrophysiological, and computational studies. Particular emphasis is placed on Syt-7-dependent regulation of synaptic transmission and neuroendocrine cell secretion. Finally, based on biochemical and structural data, we propose a mechanism to link Syt-7's role in membrane fusion with its role in subsequent fusion pore expansion via strong calcium-dependent phospholipid binding.

Original languageEnglish (US)
Pages (from-to)783-807
Number of pages25
JournalJournal of General Physiology
Issue number6
StatePublished - Jun 1 2018

ASJC Scopus subject areas

  • Physiology


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