The hemostatic and thrombotic complications of liver disease

Hannah Stowe McMurry, Janice Jou, Joseph Shatzel

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Hepatic cirrhosis leads to numerous hematologic derangements resulting in a complex and tenuously rebalanced hemostatic milieu. The utility of common hematologic tests including the INR and aPTT in assessing hemostatic and thrombotic risk in patients with cirrhosis is limited, and consensus on transfusion thresholds and proper management of thrombotic complications continues to evolve. This review summarizes the pathophysiology of key derangements of hemostasis including those of platelets, von Willebrand factor, pro- and anticoagulation factors, and fibrin. Additionally, the pathogenesis, consequences, optimal management, and prevention of major thrombotic and bleeding complications in cirrhosis arte discussed.

Original languageEnglish (US)
Pages (from-to)383-392
Number of pages10
JournalEuropean Journal of Haematology
Volume107
Issue number4
DOIs
StatePublished - Oct 2021
Externally publishedYes

Keywords

  • blood coagulation
  • hemostasis
  • humans
  • liver cirrhosis
  • thrombosis

ASJC Scopus subject areas

  • Hematology

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