The hemodynamic effects of intraoperative injection of muromonab CD3

Research output: Contribution to journalArticle

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Abstract

During anesthesia 5 mg of muromonab CD3 (OKT3), an anti-CD3 monoclonal antibody, was administered prophylactically to twelve patients undergoing cadaveric renal transplantation. Preoperatively, all patients were at or near their dry body weights. Methylprednisolone 500 mg on call to or in the operating room, azathioprine 2 mg kg-1 and diphenhydramine 50 mg were administered intraoperatively to reduce the probability and severity of reported effects of OKT3. After induction of anesthesia, the patients were monitored for changes in cardiovascular variables for up to 120 min after OKT3 administration. All patients had uneventful anesthetic courses. Analysis of variance showed no significant changes from pre-OKT3 administration in heart rate, mean blood pressure, mean pulmonary artery pressure, central venous pressure (CVP), pulmonary capillary wedge pressure (PCWP), and pulmonary vascular resistance (PVRI). CVP values were a reliable indicator of PCWP with the correlation coefficient of CVP to PCWP or r = 0.78 (P

Original languageEnglish (US)
Pages (from-to)356-358
Number of pages3
JournalTransplantation
Volume56
Issue number2
StatePublished - 1993

Fingerprint

Muromonab-CD3
Hemodynamics
Central Venous Pressure
Pulmonary Wedge Pressure
Injections
Anesthesia
Diphenhydramine
Methylprednisolone
Azathioprine
Operating Rooms
Vascular Resistance
Kidney Transplantation
Pulmonary Artery
Anesthetics
Analysis of Variance
Heart Rate
Monoclonal Antibodies
Body Weight
Blood Pressure
Pressure

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

The hemodynamic effects of intraoperative injection of muromonab CD3. / Robinson, Stephen; Barry, John; Norman, Douglas.

In: Transplantation, Vol. 56, No. 2, 1993, p. 356-358.

Research output: Contribution to journalArticle

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