The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery

Pekka Talke, Richard Chen, Brian Thomas, Anil Aggarwall, Alexandru Gottlieb, Per Thorborg, Stephen Heard, Albert Cheung, Stanley Lee Son, Antero Kallio

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

We tested dexmedetomidine, an α2 agonist that decreases heart rate, blood pressure, and plasma norepinephrine concentration, for its ability to attenuate stress responses during emergence from anesthesia after major vascular operations. Patients scheduled for vascular surgery received either dexmedetomidine (n = 22) or placebo (n = 19) IV beginning 20 min before the induction of anesthesia and continuing until 48 h after the end of surgery. All patients received standardized anesthesia. Heart rate and arterial blood pressure were kept within predetermined limits by varying anesthetic level and using vasoactive medications. Heart rate, arterial blood pressure, and inhaled anesthetic concentration were monitored continuously; additional measurements included plasma and urine catecholamines. During emergence from anesthesia, heart rate was slower with dexmedetomidine (73 ± 11 bpm) than placebo (83 ± 20 bpm) (P = 0.006), and the percentage of time the heart rate was within the predetermined hemodynamic limits was more frequent with dexmedetomidine (P <0.05). Plasma norepinephrine levels increased only in the placebo group and were significantly lower for the dexmedetomidine group during the immediate postoperative period (P = 0.0002). We conclude that dexmedetomidine attenuates increases in heart rate and plasma norepinephrine concentrations during emergence from anesthesia. Implications: The α2 agonist, dexmedetomidine, attenuates increases in heart rate and plasma norepinephrine concentrations during emergence from anesthesia in vascular surgery patients.

Original languageEnglish (US)
Pages (from-to)834-839
Number of pages6
JournalAnesthesia and Analgesia
Volume90
Issue number4
StatePublished - 2000
Externally publishedYes

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Dexmedetomidine
Adrenergic Agents
Blood Vessels
Heart Rate
Hemodynamics
Anesthesia
Norepinephrine
Placebos
Anesthetics
Arterial Pressure
Postoperative Period
Catecholamines
Urine
Blood Pressure

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Talke, P., Chen, R., Thomas, B., Aggarwall, A., Gottlieb, A., Thorborg, P., ... Kallio, A. (2000). The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesthesia and Analgesia, 90(4), 834-839.

The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. / Talke, Pekka; Chen, Richard; Thomas, Brian; Aggarwall, Anil; Gottlieb, Alexandru; Thorborg, Per; Heard, Stephen; Cheung, Albert; Lee Son, Stanley; Kallio, Antero.

In: Anesthesia and Analgesia, Vol. 90, No. 4, 2000, p. 834-839.

Research output: Contribution to journalArticle

Talke, P, Chen, R, Thomas, B, Aggarwall, A, Gottlieb, A, Thorborg, P, Heard, S, Cheung, A, Lee Son, S & Kallio, A 2000, 'The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery', Anesthesia and Analgesia, vol. 90, no. 4, pp. 834-839.
Talke P, Chen R, Thomas B, Aggarwall A, Gottlieb A, Thorborg P et al. The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesthesia and Analgesia. 2000;90(4):834-839.
Talke, Pekka ; Chen, Richard ; Thomas, Brian ; Aggarwall, Anil ; Gottlieb, Alexandru ; Thorborg, Per ; Heard, Stephen ; Cheung, Albert ; Lee Son, Stanley ; Kallio, Antero. / The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. In: Anesthesia and Analgesia. 2000 ; Vol. 90, No. 4. pp. 834-839.
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