The hematopoietic microenvironment in the elderly: Defects in IL-1-induced CSF expression in vitro

M. A. Lee, G. M. Segal, G. C. Bagby

    Research output: Contribution to journalArticle

    30 Scopus citations

    Abstract

    The expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) genes by stromal cells of the hematopoietic microenvironment is regulated, in vitro, by interleukin 1α (IL-1α) and IL-1β. We reasoned that malfunction of this inductive mechanism in vivo might contribute to the intolerance of the aged to myelosuppressive therapy. We found that bone marrow fibroblasts from healthy elderly (ages 65-75 years) volunteers were less sensitive to the inductive effects of recombinant IL-1β than were marrow fibroblasts from younger volunteers, and we propose that an age-related decline in sensitivity of marrow stroma to IL-1 may impair the ability of the elderly to increase production of hematopoietic growth factors under conditions of physiologic stress.

    Original languageEnglish (US)
    Pages (from-to)952-956
    Number of pages5
    JournalExperimental hematology
    Volume17
    Issue number9
    StatePublished - Jan 1 1989

      Fingerprint

    ASJC Scopus subject areas

    • Molecular Biology
    • Hematology
    • Genetics
    • Cell Biology
    • Cancer Research

    Cite this