The health impact of adult cervical deformity in patients presenting for surgical treatment

Comparison to United States population norms and chronic disease states based on the EuroQuol-5 dimensions questionnaire

Justin S. Smith, Breton Line, Shay Bess, Christopher I. Shaffrey, Han Jo Kim, Gregory Mundis, Justin K. Scheer, Eric Klineberg, Michael O'Brien, Richard Hostin, Munish Gupta, Alan Daniels, Michael Kelly, Jeffrey L. Gum, Frank J. Schwab, Virginie Lafage, Renaud Lafage, Tamir Ailon, Peter Passias, Themistocles Protopsaltis & 7 others Todd J. Albert, K. Daniel Riew, Robert Hart, Doug Burton, Vedat Deviren, Christopher P. Ames, Paul Park

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

BACKGROUND: Although adult cervical spine deformity (ACSD) is associated with pain and disability, its health impact has not been quantified in comparison to other chronic diseases. OBJECTIVE: To perform a comparative analysis of the health impact of symptomatic ACSD to US normative and chronic disease values using EQ-5D (EuroQuol-5 Dimensions questionnaire) scores. METHODS: ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database. Baseline demographics and EQ-5D scores were collected and compared with US normative and disease state values. RESULTS: Of 121 ACSD patients, 115 (95%) completed the EQ-5D (60% women, mean age 61 years, previous spine surgery in 44%). Diagnoses included kyphosis with mid-cervical (63.4%), cervico-thoracic (23.5%), or thoracic (8.7%) apex and primary coronal deformity (4.3%). The mean ACSD EQ-5D index was 0.511 (standard definition = 0.224), which is 34% below the bottom 25th percentile (0.780) for similar age- and gender-matched US normative populations. Mean ACSD EQ-5D index values were worse than the bottom 25th percentile for several other disease states, including chronic ischemic heart disease (0.708), malignant breast cancer (0.708), and malignant prostate cancer (0.708). ACSD mean index values were comparable to the bottom 25th percentile values for blindness/low vision (0.543), emphysema (0.508), renal failure (0.506), and stroke (0.463). EQ-5D scores did not significantly differ based on cervical deformity type (P =.66). CONCLUSION: The health impact of symptomatic ACSD is substantial, with negative impact across all EQ-5D domains. The mean ACSD EQ-5D index was comparable to the bottom 25th percentile values for blindness/low vision, emphysema, renal failure, and stroke.

Original languageEnglish (US)
Pages (from-to)716-725
Number of pages10
JournalClinical Neurosurgery
Volume80
Issue number5
DOIs
StatePublished - Jan 1 2017

Fingerprint

Spine
Chronic Disease
Health
Population
Therapeutics
Low Vision
Emphysema
Blindness
Renal Insufficiency
Thorax
Stroke
Surveys and Questionnaires
Kyphosis
Myocardial Ischemia
Prostatic Neoplasms
Demography
Databases
Breast Neoplasms
Pain

Keywords

  • Adult
  • Cervical deformity
  • Cervical kyphosis
  • Disability
  • EQ-5D
  • EQ-5D-3L
  • Health impact
  • Spine

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

The health impact of adult cervical deformity in patients presenting for surgical treatment : Comparison to United States population norms and chronic disease states based on the EuroQuol-5 dimensions questionnaire. / Smith, Justin S.; Line, Breton; Bess, Shay; Shaffrey, Christopher I.; Kim, Han Jo; Mundis, Gregory; Scheer, Justin K.; Klineberg, Eric; O'Brien, Michael; Hostin, Richard; Gupta, Munish; Daniels, Alan; Kelly, Michael; Gum, Jeffrey L.; Schwab, Frank J.; Lafage, Virginie; Lafage, Renaud; Ailon, Tamir; Passias, Peter; Protopsaltis, Themistocles; Albert, Todd J.; Riew, K. Daniel; Hart, Robert; Burton, Doug; Deviren, Vedat; Ames, Christopher P.; Park, Paul.

In: Clinical Neurosurgery, Vol. 80, No. 5, 01.01.2017, p. 716-725.

Research output: Contribution to journalArticle

Smith, JS, Line, B, Bess, S, Shaffrey, CI, Kim, HJ, Mundis, G, Scheer, JK, Klineberg, E, O'Brien, M, Hostin, R, Gupta, M, Daniels, A, Kelly, M, Gum, JL, Schwab, FJ, Lafage, V, Lafage, R, Ailon, T, Passias, P, Protopsaltis, T, Albert, TJ, Riew, KD, Hart, R, Burton, D, Deviren, V, Ames, CP & Park, P 2017, 'The health impact of adult cervical deformity in patients presenting for surgical treatment: Comparison to United States population norms and chronic disease states based on the EuroQuol-5 dimensions questionnaire', Clinical Neurosurgery, vol. 80, no. 5, pp. 716-725. https://doi.org/10.1093/neuros/nyx028
Smith, Justin S. ; Line, Breton ; Bess, Shay ; Shaffrey, Christopher I. ; Kim, Han Jo ; Mundis, Gregory ; Scheer, Justin K. ; Klineberg, Eric ; O'Brien, Michael ; Hostin, Richard ; Gupta, Munish ; Daniels, Alan ; Kelly, Michael ; Gum, Jeffrey L. ; Schwab, Frank J. ; Lafage, Virginie ; Lafage, Renaud ; Ailon, Tamir ; Passias, Peter ; Protopsaltis, Themistocles ; Albert, Todd J. ; Riew, K. Daniel ; Hart, Robert ; Burton, Doug ; Deviren, Vedat ; Ames, Christopher P. ; Park, Paul. / The health impact of adult cervical deformity in patients presenting for surgical treatment : Comparison to United States population norms and chronic disease states based on the EuroQuol-5 dimensions questionnaire. In: Clinical Neurosurgery. 2017 ; Vol. 80, No. 5. pp. 716-725.
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abstract = "BACKGROUND: Although adult cervical spine deformity (ACSD) is associated with pain and disability, its health impact has not been quantified in comparison to other chronic diseases. OBJECTIVE: To perform a comparative analysis of the health impact of symptomatic ACSD to US normative and chronic disease values using EQ-5D (EuroQuol-5 Dimensions questionnaire) scores. METHODS: ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database. Baseline demographics and EQ-5D scores were collected and compared with US normative and disease state values. RESULTS: Of 121 ACSD patients, 115 (95{\%}) completed the EQ-5D (60{\%} women, mean age 61 years, previous spine surgery in 44{\%}). Diagnoses included kyphosis with mid-cervical (63.4{\%}), cervico-thoracic (23.5{\%}), or thoracic (8.7{\%}) apex and primary coronal deformity (4.3{\%}). The mean ACSD EQ-5D index was 0.511 (standard definition = 0.224), which is 34{\%} below the bottom 25th percentile (0.780) for similar age- and gender-matched US normative populations. Mean ACSD EQ-5D index values were worse than the bottom 25th percentile for several other disease states, including chronic ischemic heart disease (0.708), malignant breast cancer (0.708), and malignant prostate cancer (0.708). ACSD mean index values were comparable to the bottom 25th percentile values for blindness/low vision (0.543), emphysema (0.508), renal failure (0.506), and stroke (0.463). EQ-5D scores did not significantly differ based on cervical deformity type (P =.66). CONCLUSION: The health impact of symptomatic ACSD is substantial, with negative impact across all EQ-5D domains. The mean ACSD EQ-5D index was comparable to the bottom 25th percentile values for blindness/low vision, emphysema, renal failure, and stroke.",
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T1 - The health impact of adult cervical deformity in patients presenting for surgical treatment

T2 - Comparison to United States population norms and chronic disease states based on the EuroQuol-5 dimensions questionnaire

AU - Smith, Justin S.

AU - Line, Breton

AU - Bess, Shay

AU - Shaffrey, Christopher I.

AU - Kim, Han Jo

AU - Mundis, Gregory

AU - Scheer, Justin K.

AU - Klineberg, Eric

AU - O'Brien, Michael

AU - Hostin, Richard

AU - Gupta, Munish

AU - Daniels, Alan

AU - Kelly, Michael

AU - Gum, Jeffrey L.

AU - Schwab, Frank J.

AU - Lafage, Virginie

AU - Lafage, Renaud

AU - Ailon, Tamir

AU - Passias, Peter

AU - Protopsaltis, Themistocles

AU - Albert, Todd J.

AU - Riew, K. Daniel

AU - Hart, Robert

AU - Burton, Doug

AU - Deviren, Vedat

AU - Ames, Christopher P.

AU - Park, Paul

PY - 2017/1/1

Y1 - 2017/1/1

N2 - BACKGROUND: Although adult cervical spine deformity (ACSD) is associated with pain and disability, its health impact has not been quantified in comparison to other chronic diseases. OBJECTIVE: To perform a comparative analysis of the health impact of symptomatic ACSD to US normative and chronic disease values using EQ-5D (EuroQuol-5 Dimensions questionnaire) scores. METHODS: ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database. Baseline demographics and EQ-5D scores were collected and compared with US normative and disease state values. RESULTS: Of 121 ACSD patients, 115 (95%) completed the EQ-5D (60% women, mean age 61 years, previous spine surgery in 44%). Diagnoses included kyphosis with mid-cervical (63.4%), cervico-thoracic (23.5%), or thoracic (8.7%) apex and primary coronal deformity (4.3%). The mean ACSD EQ-5D index was 0.511 (standard definition = 0.224), which is 34% below the bottom 25th percentile (0.780) for similar age- and gender-matched US normative populations. Mean ACSD EQ-5D index values were worse than the bottom 25th percentile for several other disease states, including chronic ischemic heart disease (0.708), malignant breast cancer (0.708), and malignant prostate cancer (0.708). ACSD mean index values were comparable to the bottom 25th percentile values for blindness/low vision (0.543), emphysema (0.508), renal failure (0.506), and stroke (0.463). EQ-5D scores did not significantly differ based on cervical deformity type (P =.66). CONCLUSION: The health impact of symptomatic ACSD is substantial, with negative impact across all EQ-5D domains. The mean ACSD EQ-5D index was comparable to the bottom 25th percentile values for blindness/low vision, emphysema, renal failure, and stroke.

AB - BACKGROUND: Although adult cervical spine deformity (ACSD) is associated with pain and disability, its health impact has not been quantified in comparison to other chronic diseases. OBJECTIVE: To perform a comparative analysis of the health impact of symptomatic ACSD to US normative and chronic disease values using EQ-5D (EuroQuol-5 Dimensions questionnaire) scores. METHODS: ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database. Baseline demographics and EQ-5D scores were collected and compared with US normative and disease state values. RESULTS: Of 121 ACSD patients, 115 (95%) completed the EQ-5D (60% women, mean age 61 years, previous spine surgery in 44%). Diagnoses included kyphosis with mid-cervical (63.4%), cervico-thoracic (23.5%), or thoracic (8.7%) apex and primary coronal deformity (4.3%). The mean ACSD EQ-5D index was 0.511 (standard definition = 0.224), which is 34% below the bottom 25th percentile (0.780) for similar age- and gender-matched US normative populations. Mean ACSD EQ-5D index values were worse than the bottom 25th percentile for several other disease states, including chronic ischemic heart disease (0.708), malignant breast cancer (0.708), and malignant prostate cancer (0.708). ACSD mean index values were comparable to the bottom 25th percentile values for blindness/low vision (0.543), emphysema (0.508), renal failure (0.506), and stroke (0.463). EQ-5D scores did not significantly differ based on cervical deformity type (P =.66). CONCLUSION: The health impact of symptomatic ACSD is substantial, with negative impact across all EQ-5D domains. The mean ACSD EQ-5D index was comparable to the bottom 25th percentile values for blindness/low vision, emphysema, renal failure, and stroke.

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KW - Cervical deformity

KW - Cervical kyphosis

KW - Disability

KW - EQ-5D

KW - EQ-5D-3L

KW - Health impact

KW - Spine

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