The harmonies played by TGF-β in stem cell biology

Naoki Oshimori, Elaine Fuchs

Research output: Contribution to journalReview article

107 Citations (Scopus)

Abstract

To rejuvenate tissues and/or repair wounds, stem cells must receive extrinsic signals from their surrounding environment and integrate them with their intrinsic abilities to self-renew and differentiate to make tissues. Increasing evidence suggests that the superfamily of transforming growth factor-βs (TGF-βs) constitute integral components in the intercellular crosstalk between stem cells and their microenvironment. In this review, we summarize recent advances in our understanding of TGF-β superfamily functions in embryonic and adult stem cells. We discuss how these pathways help to define the physiological environment where stem cells reside, and how perturbations in the signaling circuitry contribute to cancers.

Original languageEnglish (US)
Pages (from-to)751-764
Number of pages14
JournalCell Stem Cell
Volume11
Issue number6
DOIs
StatePublished - Dec 7 2012
Externally publishedYes

Fingerprint

Cell Biology
Stem Cells
Stem Cell Niche
Adult Stem Cells
Transforming Growth Factors
Embryonic Stem Cells
Wounds and Injuries
Neoplasms

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine
  • Genetics

Cite this

The harmonies played by TGF-β in stem cell biology. / Oshimori, Naoki; Fuchs, Elaine.

In: Cell Stem Cell, Vol. 11, No. 6, 07.12.2012, p. 751-764.

Research output: Contribution to journalReview article

Oshimori, Naoki ; Fuchs, Elaine. / The harmonies played by TGF-β in stem cell biology. In: Cell Stem Cell. 2012 ; Vol. 11, No. 6. pp. 751-764.
@article{bd747241ffdf4c58a4a3d653adf745df,
title = "The harmonies played by TGF-β in stem cell biology",
abstract = "To rejuvenate tissues and/or repair wounds, stem cells must receive extrinsic signals from their surrounding environment and integrate them with their intrinsic abilities to self-renew and differentiate to make tissues. Increasing evidence suggests that the superfamily of transforming growth factor-βs (TGF-βs) constitute integral components in the intercellular crosstalk between stem cells and their microenvironment. In this review, we summarize recent advances in our understanding of TGF-β superfamily functions in embryonic and adult stem cells. We discuss how these pathways help to define the physiological environment where stem cells reside, and how perturbations in the signaling circuitry contribute to cancers.",
author = "Naoki Oshimori and Elaine Fuchs",
year = "2012",
month = "12",
day = "7",
doi = "10.1016/j.stem.2012.11.001",
language = "English (US)",
volume = "11",
pages = "751--764",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - The harmonies played by TGF-β in stem cell biology

AU - Oshimori, Naoki

AU - Fuchs, Elaine

PY - 2012/12/7

Y1 - 2012/12/7

N2 - To rejuvenate tissues and/or repair wounds, stem cells must receive extrinsic signals from their surrounding environment and integrate them with their intrinsic abilities to self-renew and differentiate to make tissues. Increasing evidence suggests that the superfamily of transforming growth factor-βs (TGF-βs) constitute integral components in the intercellular crosstalk between stem cells and their microenvironment. In this review, we summarize recent advances in our understanding of TGF-β superfamily functions in embryonic and adult stem cells. We discuss how these pathways help to define the physiological environment where stem cells reside, and how perturbations in the signaling circuitry contribute to cancers.

AB - To rejuvenate tissues and/or repair wounds, stem cells must receive extrinsic signals from their surrounding environment and integrate them with their intrinsic abilities to self-renew and differentiate to make tissues. Increasing evidence suggests that the superfamily of transforming growth factor-βs (TGF-βs) constitute integral components in the intercellular crosstalk between stem cells and their microenvironment. In this review, we summarize recent advances in our understanding of TGF-β superfamily functions in embryonic and adult stem cells. We discuss how these pathways help to define the physiological environment where stem cells reside, and how perturbations in the signaling circuitry contribute to cancers.

UR - http://www.scopus.com/inward/record.url?scp=84870875424&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870875424&partnerID=8YFLogxK

U2 - 10.1016/j.stem.2012.11.001

DO - 10.1016/j.stem.2012.11.001

M3 - Review article

C2 - 23217421

AN - SCOPUS:84870875424

VL - 11

SP - 751

EP - 764

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 6

ER -