TY - JOUR
T1 - The hair cell's transduction channel
AU - Strassmaier, Meredith
AU - Gillespie, Peter G.
N1 - Funding Information:
We thank Richard Walker for comments on the manuscript. Research in the Gillespie laboratory is supported by the National Institutes of Health (grants DC02368, DC03279, and DC04571).
PY - 2002/8/1
Y1 - 2002/8/1
N2 - The elusive transduction channel is the key player in mechanical transduction by the sensory hair cells of the inner ear. Multiple factors have thwarted molecular identification of this channel, including the lack of a definitive pharmacological signature, the paucity of hair cells, and the uniqueness of their transduction mechanism. At present, we are forced to speculate as to the transduction channel's identity; functional characteristics suggest, however, that it may well belong to transient receptor potential superfamily of ion channels.
AB - The elusive transduction channel is the key player in mechanical transduction by the sensory hair cells of the inner ear. Multiple factors have thwarted molecular identification of this channel, including the lack of a definitive pharmacological signature, the paucity of hair cells, and the uniqueness of their transduction mechanism. At present, we are forced to speculate as to the transduction channel's identity; functional characteristics suggest, however, that it may well belong to transient receptor potential superfamily of ion channels.
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U2 - 10.1016/S0959-4388(02)00344-6
DO - 10.1016/S0959-4388(02)00344-6
M3 - Review article
C2 - 12139984
AN - SCOPUS:0036683862
VL - 12
SP - 380
EP - 386
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 4
ER -