The haemodynamic effects of propofol in combination with ephedrine in elderly patients (ASA groups 3 and 4)

F. Gamlin, J. Freeman, L. Winslow, J. Berridge, M. Vucevic

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The marked vasodilator and negative inotropic affects of propofol are disadvantages in frail elderly patients. We investigated the safety and efficacy of adding different doses of ephedrine to propofol in order to obtund the hypotensive reponse. The haemodynamic effects of adding 15, 20 or 25 mg of ephedrine to 200 mg of propofol were compared to control in 40 ASA 3/4 patients over 60 years presenting for genito-urinary surgery. The addition of ephedrine to propofol appears to be an effective method of obtunding the hypotensive response to propofol at all doses used in this study. However, marked tachycardia associated with the use of ephedrine in combination with propofol occurred in the majority of patients, occasionally reaching high levels in individual patients. Due to the risk of this tachycardia inducing myocardial ischemia, we would not recommend the use in elderly patients of any of the ephedrine/propofol mixtures studied.

Original languageEnglish (US)
Pages (from-to)477-480
Number of pages4
JournalAnaesthesia and intensive care
Volume27
Issue number5
StatePublished - Oct 1 1999

Keywords

  • Anaesthetics, intravenous: propofol
  • Complications: arrhythmia, tachycardia
  • Sympathetic nervous system: pharmacology, ephedrine, tachycardia

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Anesthesiology and Pain Medicine

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    Gamlin, F., Freeman, J., Winslow, L., Berridge, J., & Vucevic, M. (1999). The haemodynamic effects of propofol in combination with ephedrine in elderly patients (ASA groups 3 and 4). Anaesthesia and intensive care, 27(5), 477-480.