The gut in trauma

Jayshil J. Patel; Martin D. Rosenthal; Keith R. Miller; Robert G. Martindale

doi:10.1097/MCC.0000000000000331

The gut in trauma

Jayshil J. Patel, Martin D. Rosenthal, Keith R. Miller, Robert G. Martindale

Surgery

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Despite resuscitation, gut dysfunction promotes distant organ injury. In addition, postresuscitation nosocomial and iatrogenic 'hits' exaggerate the immune response, contributing to MODS. This was a provocative concept, suggesting infectious and noninfectious causes of inflammation may trigger, heighten, and perpetuate an inflammatory response culminating in MODS and death. Emerging evidence suggests posttraumatic injury mechanisms, such as intestinal mucosal disruption and shifting of the gut microbiome to a pathobiome. In addition, traumatic brain injury activates the gut-brain axis and increases intestinal permeability.

Original language	English (US)
Pages (from-to)	339-346
Number of pages	8
Journal	Current Opinion in Critical Care
Volume	22
Issue number	4
DOIs	https://doi.org/10.1097/MCC.0000000000000331
State	Published - Aug 1 2016

Keywords

gut dysfunction
multiple organ dysfunction syndrome
trauma

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

Access to Document

10.1097/MCC.0000000000000331

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AB - Despite resuscitation, gut dysfunction promotes distant organ injury. In addition, postresuscitation nosocomial and iatrogenic 'hits' exaggerate the immune response, contributing to MODS. This was a provocative concept, suggesting infectious and noninfectious causes of inflammation may trigger, heighten, and perpetuate an inflammatory response culminating in MODS and death. Emerging evidence suggests posttraumatic injury mechanisms, such as intestinal mucosal disruption and shifting of the gut microbiome to a pathobiome. In addition, traumatic brain injury activates the gut-brain axis and increases intestinal permeability.

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