The gut in trauma

Jayshil J. Patel, Martin D. Rosenthal, Keith R. Miller, Robert G. Martindale

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Despite resuscitation, gut dysfunction promotes distant organ injury. In addition, postresuscitation nosocomial and iatrogenic 'hits' exaggerate the immune response, contributing to MODS. This was a provocative concept, suggesting infectious and noninfectious causes of inflammation may trigger, heighten, and perpetuate an inflammatory response culminating in MODS and death. Emerging evidence suggests posttraumatic injury mechanisms, such as intestinal mucosal disruption and shifting of the gut microbiome to a pathobiome. In addition, traumatic brain injury activates the gut-brain axis and increases intestinal permeability.

Original languageEnglish (US)
Pages (from-to)339-346
Number of pages8
JournalCurrent Opinion in Critical Care
Volume22
Issue number4
DOIs
StatePublished - Aug 1 2016

Keywords

  • gut dysfunction
  • multiple organ dysfunction syndrome
  • trauma

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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