The growth hormone-insulin-like growth factor-I axis in chronic kidney disease

Robert H. Mak, Wai W. Cheung, Charles T. Roberts

    Research output: Contribution to journalReview articlepeer-review

    57 Scopus citations


    Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are important physiologic regulators of growth, body composition, and kidney function. Perturbations in the GH-IGF-I axis are responsible for many important complications seen in chronic kidney disease (CKD), such as growth retardation and cachectic wasting, as well as disease progression. Recent evidence suggests that CKD is characterized by abnormalities in GH and IGF-I signal transduction and the interaction of these pathways with those that involve other molecules such as ghrelin, myostatin, and the suppressor of cytokine signaling (SOCS) family. Further understanding of GH/IGF pathophysiology in CKD may lead to the development of therapeutic strategies for these devastating complications, which are associated with high rates of mortality and morbidity.

    Original languageEnglish (US)
    Pages (from-to)17-25
    Number of pages9
    JournalGrowth Hormone and IGF Research
    Issue number1
    StatePublished - Feb 2008


    • Chronic kidney disease
    • Ghrelin
    • Growth hormone
    • Insulin-like growth factors
    • Myostatin
    • Suppressor of cytokine signaling

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology


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