The growth hormone cascade and its role in mammalian growth

Ronald (Ron) Rosenfeld, Vivian Hwa

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The myriad actions of growth hormone (GH) are still incompletely understood, despite decades of research. Although it is a major regulator of post-natal growth in mammals, much of its effects on skeletal growth are recognized to be mediated indirectly, through the stimulation of production of insulin-like growth factor (IGF)-I, as well as some of the major serum carrier proteins for IGF-I and -II, such as IGF-binding protein-3 (IGFBP-3) and the acid-labile subunit (ALS). The regulation of IGF-I production by GH appears to be mediated entirely by signalling through the Janus kinase (JAK) 2 pathway, via the phosphorylation of the transcription factor, signal transducer and activator of transcription (STAT) 5b. GH also signals, however, through additional pathways that are likely to be critical to the metabolic actions of GH.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalHormone Research
Volume71
Issue numberSUPPL. 2
DOIs
StatePublished - Apr 2009
Externally publishedYes

Fingerprint

Growth Hormone
Insulin-Like Growth Factor I
Growth
STAT5 Transcription Factor
Janus Kinase 2
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor II
Blood Proteins
Mammals
Carrier Proteins
Transcription Factors
Phosphorylation
Research

Keywords

  • Growth hormone
  • Insulin-like growth factor (IGF)
  • JAK2
  • Signal transducer and activator of transcription (STAT)

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The growth hormone cascade and its role in mammalian growth. / Rosenfeld, Ronald (Ron); Hwa, Vivian.

In: Hormone Research, Vol. 71, No. SUPPL. 2, 04.2009, p. 36-40.

Research output: Contribution to journalArticle

Rosenfeld, Ronald (Ron) ; Hwa, Vivian. / The growth hormone cascade and its role in mammalian growth. In: Hormone Research. 2009 ; Vol. 71, No. SUPPL. 2. pp. 36-40.
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