The Glucagonoma Syndrome (Necrolytic Migratory Erythema) and Zinc

Robert B. Amon, Keith H. Swenson, Jon M. Hanifin, K. Michael Hambidge

Research output: Contribution to journalLetterpeer-review

14 Scopus citations


To the Editor: We agree with Drs. Tasman-Jones and Kay (N Engl J Med 293:830, 1975) that the skin lesions that occur in patients with the glucagonoma syndrome closely mirror those present in patients with acute zinc deficiency. Recently, however, we had the opportunity to diagnose and manage a 19-year-old woman with the glucagonoma syndrome whose serum zinc level was 93 μg per 100 ml (normal, 68 to 110). The diagnosis was established on the basis of clinical signs (necrolytic migratory erythema and glossitis), a fivefold elevation of plasma glucagon levels and electron microscopy of surgical tissue demonstrating the. . . No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number17
StatePublished - Oct 21 1976

ASJC Scopus subject areas

  • Medicine(all)


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