The Glucagonoma Syndrome: A Distinctive Cutaneous Marker of Systemic Disease

Keith H. Swenson, Robert B. Amon, Jon Hanifin

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The glucagonoma syndrome is a rare clinical condition characterized by a distinctive cutaneous eruption associated with a glucagon-secreting islet cell neoplasm of the pancreas. A 19-year-old woman manifested typical features of this condition: a polymorphous skin eruption with characteristic distribution of lesions in perioral and paragenital regions; lesions in sites of cutaneous trauma; a skin biopsy that showed epidermal cleavage; glossitis; weight loss; mild anemia; abnormal glucose tolerance test results. Plasma glucagon levels, determined by radioimmunoassay, were approximately five times normal. Angiography indicated a pancreatic tumor with liver metastases. Islet cell origin was confirmed histologically. It is hoped that wider recognition of the distinctive clinical features of this syndrome will result in earlier detection and possible surgical cure of the underlying malignancy.

Original languageEnglish (US)
Pages (from-to)224-228
Number of pages5
JournalArchives of Dermatology
Volume114
Issue number2
DOIs
StatePublished - 1978

Fingerprint

Glucagonoma
Skin
Islets of Langerhans
Glossitis
Glucagon-Secreting Cells
Glucose Tolerance Test
Glucagon
Pancreatic Neoplasms
Radioimmunoassay
Anemia
Weight Loss
Neoplasms
Angiography
Neoplasm Metastasis
Biopsy
Liver
Wounds and Injuries

ASJC Scopus subject areas

  • Dermatology

Cite this

The Glucagonoma Syndrome : A Distinctive Cutaneous Marker of Systemic Disease. / Swenson, Keith H.; Amon, Robert B.; Hanifin, Jon.

In: Archives of Dermatology, Vol. 114, No. 2, 1978, p. 224-228.

Research output: Contribution to journalArticle

Swenson, Keith H. ; Amon, Robert B. ; Hanifin, Jon. / The Glucagonoma Syndrome : A Distinctive Cutaneous Marker of Systemic Disease. In: Archives of Dermatology. 1978 ; Vol. 114, No. 2. pp. 224-228.
@article{e074e595e9c543369995116985137f31,
title = "The Glucagonoma Syndrome: A Distinctive Cutaneous Marker of Systemic Disease",
abstract = "The glucagonoma syndrome is a rare clinical condition characterized by a distinctive cutaneous eruption associated with a glucagon-secreting islet cell neoplasm of the pancreas. A 19-year-old woman manifested typical features of this condition: a polymorphous skin eruption with characteristic distribution of lesions in perioral and paragenital regions; lesions in sites of cutaneous trauma; a skin biopsy that showed epidermal cleavage; glossitis; weight loss; mild anemia; abnormal glucose tolerance test results. Plasma glucagon levels, determined by radioimmunoassay, were approximately five times normal. Angiography indicated a pancreatic tumor with liver metastases. Islet cell origin was confirmed histologically. It is hoped that wider recognition of the distinctive clinical features of this syndrome will result in earlier detection and possible surgical cure of the underlying malignancy.",
author = "Swenson, {Keith H.} and Amon, {Robert B.} and Jon Hanifin",
year = "1978",
doi = "10.1001/archderm.1978.01640140042010",
language = "English (US)",
volume = "114",
pages = "224--228",
journal = "JAMA Dermatology",
issn = "2168-6068",
publisher = "American Medical Association",
number = "2",

}

TY - JOUR

T1 - The Glucagonoma Syndrome

T2 - A Distinctive Cutaneous Marker of Systemic Disease

AU - Swenson, Keith H.

AU - Amon, Robert B.

AU - Hanifin, Jon

PY - 1978

Y1 - 1978

N2 - The glucagonoma syndrome is a rare clinical condition characterized by a distinctive cutaneous eruption associated with a glucagon-secreting islet cell neoplasm of the pancreas. A 19-year-old woman manifested typical features of this condition: a polymorphous skin eruption with characteristic distribution of lesions in perioral and paragenital regions; lesions in sites of cutaneous trauma; a skin biopsy that showed epidermal cleavage; glossitis; weight loss; mild anemia; abnormal glucose tolerance test results. Plasma glucagon levels, determined by radioimmunoassay, were approximately five times normal. Angiography indicated a pancreatic tumor with liver metastases. Islet cell origin was confirmed histologically. It is hoped that wider recognition of the distinctive clinical features of this syndrome will result in earlier detection and possible surgical cure of the underlying malignancy.

AB - The glucagonoma syndrome is a rare clinical condition characterized by a distinctive cutaneous eruption associated with a glucagon-secreting islet cell neoplasm of the pancreas. A 19-year-old woman manifested typical features of this condition: a polymorphous skin eruption with characteristic distribution of lesions in perioral and paragenital regions; lesions in sites of cutaneous trauma; a skin biopsy that showed epidermal cleavage; glossitis; weight loss; mild anemia; abnormal glucose tolerance test results. Plasma glucagon levels, determined by radioimmunoassay, were approximately five times normal. Angiography indicated a pancreatic tumor with liver metastases. Islet cell origin was confirmed histologically. It is hoped that wider recognition of the distinctive clinical features of this syndrome will result in earlier detection and possible surgical cure of the underlying malignancy.

UR - http://www.scopus.com/inward/record.url?scp=0017934218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017934218&partnerID=8YFLogxK

U2 - 10.1001/archderm.1978.01640140042010

DO - 10.1001/archderm.1978.01640140042010

M3 - Article

C2 - 204256

AN - SCOPUS:0017934218

VL - 114

SP - 224

EP - 228

JO - JAMA Dermatology

JF - JAMA Dermatology

SN - 2168-6068

IS - 2

ER -