The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: An NTM-NET collaborative study

Wouter Hoefsloot; Jakko Van Ingen; Claire Andrejak; Kristian Ängeby; Rosine Bauriaud; Pascale Bemer; Natalie Beylis; Martin J. Boeree; Juana Cacho; Violet Chihota; Erica Chimara; Gavin Churchyard; Raquel Cias; Rosa Daza; Charles L. Daley; P. N.Richard Dekhuijzen; Diego Domingo; Francis Drobniewski; Jaime Esteban; Maryse Fauville-Dufaux; Dorte Bek Folkvardsen; Noel Gibbons; Enrique Gómez-Mampaso; Rosa Gonzalez; Harald Hoffmann; Po Ren Hsueh; Alexander Indra; Tomasz Jagielski; Frances Jamieson; Mateja Jankovic; Eefje Jong; Joseph Keane; Wo Jung Koh; Berit Lange; Sylvia Leao; Rita Macedo; Turid Mannsåker; Theodore K. Marras; Jeannette Maugein; Heather J. Milburn; Tamas Mlinkó; Nora Morcillo; Kozo Morimoto; Dimitrios Papaventsis; Elia Palenque; Mar Paez-Peña; Claudio Piersimoni; Monika Polanová; Nalin Rastogi; Elvira Richter; Maria Jesus Ruiz-Serrano; Anabela Silva; M. Pedro Da Silva; Hulya Simsek; Dick Van Soolingen; Nora Szabó; Rachel Thomson; Teresa Tórtola Fernandez; Enrico Tortoli; Sarah E. Totten; Greg Tyrrell; Tuula Vasankari; Miguel Villar; Renata Walkiewicz; Kevin L. Winthrop; Dirk Wagner

doi:10.1183/09031936.00149212

The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: An NTM-NET collaborative study

Wouter Hoefsloot, Jakko Van Ingen, Claire Andrejak, Kristian Ängeby, Rosine Bauriaud, Pascale Bemer, Natalie Beylis, Martin J. Boeree, Juana Cacho, Violet Chihota, Erica Chimara, Gavin Churchyard, Raquel Cias, Rosa Daza, Charles L. Daley, P. N.Richard Dekhuijzen, Diego Domingo, Francis Drobniewski, Jaime Esteban, Maryse Fauville-DufauxDorte Bek Folkvardsen, Noel Gibbons, Enrique Gómez-Mampaso, Rosa Gonzalez, Harald Hoffmann, Po Ren Hsueh, Alexander Indra, Tomasz Jagielski, Frances Jamieson, Mateja Jankovic, Eefje Jong, Joseph Keane, Wo Jung Koh, Berit Lange, Sylvia Leao, Rita Macedo, Turid Mannsåker, Theodore K. Marras, Jeannette Maugein, Heather J. Milburn, Tamas Mlinkó, Nora Morcillo, Kozo Morimoto, Dimitrios Papaventsis, Elia Palenque, Mar Paez-Peña, Claudio Piersimoni, Monika Polanová, Nalin Rastogi, Elvira Richter, Maria Jesus Ruiz-Serrano, Anabela Silva, M. Pedro Da Silva, Hulya Simsek, Dick Van Soolingen, Nora Szabó, Rachel Thomson, Teresa Tórtola Fernandez, Enrico Tortoli, Sarah E. Totten, Greg Tyrrell, Tuula Vasankari, Miguel Villar, Renata Walkiewicz, Kevin L. Winthrop, Dirk Wagner

School Of Public Health

Research output: Contribution to journal › Article › peer-review

610 Scopus citations

Abstract

A significant knowledge gap exists concerning the geographical distribution of nontuberculous mycobacteria (NTM) isolation worldwide. To provide a snapshot of NTM species distribution, global partners in the NTM-Network European Trials Group (NET) framework (www.ntm-net.org), a branch of the Tuberculosis Network European Trials Group (TB-NET), provided identification results of the total number of patients in 2008 in whom NTM were isolated from pulmonary samples. From these data, we visualised the relative distribution of the different NTM found per continent and per country. We received species identification data for 20 182 patients, from 62 laboratories in 30 countries across six continents. 91 different NTM species were isolated. Mycobacterium avium complex (MAC) bacteria predominated inmost countries, followed by M. gordonae and M. xenopi. Important differences in geographical distribution of MAC species as well as M. xenopi, M. kansasii and rapid-growing mycobacteria were observed. This snapshot demonstrates that the species distribution among NTM isolates from pulmonary specimens in the year 2008 differed by continent and differed by country within these continents. These differences in species distribution may partly determine the frequency and manifestations of pulmonary NTM disease in each geographical location.

Original language	English (US)
Pages (from-to)	1604-1613
Number of pages	10
Journal	European Respiratory Journal
Volume	42
Issue number	6
DOIs	https://doi.org/10.1183/09031936.00149212
State	Published - Dec 1 2013

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1183/09031936.00149212

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Hoefsloot, W., Van Ingen, J., Andrejak, C., Ängeby, K., Bauriaud, R., Bemer, P., Beylis, N., Boeree, M. J., Cacho, J., Chihota, V., Chimara, E., Churchyard, G., Cias, R., Daza, R., Daley, C. L., Dekhuijzen, P. N. R., Domingo, D., Drobniewski, F., Esteban, J., ... Wagner, D. (2013). The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: An NTM-NET collaborative study. European Respiratory Journal, 42(6), 1604-1613. https://doi.org/10.1183/09031936.00149212

Hoefsloot, W, Van Ingen, J, Andrejak, C, Ängeby, K, Bauriaud, R, Bemer, P, Beylis, N, Boeree, MJ, Cacho, J, Chihota, V, Chimara, E, Churchyard, G, Cias, R, Daza, R, Daley, CL, Dekhuijzen, PNR, Domingo, D, Drobniewski, F, Esteban, J, Fauville-Dufaux, M, Folkvardsen, DB, Gibbons, N, Gómez-Mampaso, E, Gonzalez, R, Hoffmann, H, Hsueh, PR, Indra, A, Jagielski, T, Jamieson, F, Jankovic, M, Jong, E, Keane, J, Koh, WJ, Lange, B, Leao, S, Macedo, R, Mannsåker, T, Marras, TK, Maugein, J, Milburn, HJ, Mlinkó, T, Morcillo, N, Morimoto, K, Papaventsis, D, Palenque, E, Paez-Peña, M, Piersimoni, C, Polanová, M, Rastogi, N, Richter, E, Ruiz-Serrano, MJ, Silva, A, Da Silva, MP, Simsek, H, Van Soolingen, D, Szabó, N, Thomson, R, Fernandez, TT, Tortoli, E, Totten, SE, Tyrrell, G, Vasankari, T, Villar, M, Walkiewicz, R, Winthrop, KL & Wagner, D 2013, 'The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: An NTM-NET collaborative study', European Respiratory Journal, vol. 42, no. 6, pp. 1604-1613. https://doi.org/10.1183/09031936.00149212

@article{e69c03778b644727b991bf647cf76ffa,

title = "The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: An NTM-NET collaborative study",

abstract = "A significant knowledge gap exists concerning the geographical distribution of nontuberculous mycobacteria (NTM) isolation worldwide. To provide a snapshot of NTM species distribution, global partners in the NTM-Network European Trials Group (NET) framework (www.ntm-net.org), a branch of the Tuberculosis Network European Trials Group (TB-NET), provided identification results of the total number of patients in 2008 in whom NTM were isolated from pulmonary samples. From these data, we visualised the relative distribution of the different NTM found per continent and per country. We received species identification data for 20 182 patients, from 62 laboratories in 30 countries across six continents. 91 different NTM species were isolated. Mycobacterium avium complex (MAC) bacteria predominated inmost countries, followed by M. gordonae and M. xenopi. Important differences in geographical distribution of MAC species as well as M. xenopi, M. kansasii and rapid-growing mycobacteria were observed. This snapshot demonstrates that the species distribution among NTM isolates from pulmonary specimens in the year 2008 differed by continent and differed by country within these continents. These differences in species distribution may partly determine the frequency and manifestations of pulmonary NTM disease in each geographical location.",

author = "Wouter Hoefsloot and {Van Ingen}, Jakko and Claire Andrejak and Kristian {\"A}ngeby and Rosine Bauriaud and Pascale Bemer and Natalie Beylis and Boeree, {Martin J.} and Juana Cacho and Violet Chihota and Erica Chimara and Gavin Churchyard and Raquel Cias and Rosa Daza and Daley, {Charles L.} and Dekhuijzen, {P. N.Richard} and Diego Domingo and Francis Drobniewski and Jaime Esteban and Maryse Fauville-Dufaux and Folkvardsen, {Dorte Bek} and Noel Gibbons and Enrique G{\'o}mez-Mampaso and Rosa Gonzalez and Harald Hoffmann and Hsueh, {Po Ren} and Alexander Indra and Tomasz Jagielski and Frances Jamieson and Mateja Jankovic and Eefje Jong and Joseph Keane and Koh, {Wo Jung} and Berit Lange and Sylvia Leao and Rita Macedo and Turid Manns{\aa}ker and Marras, {Theodore K.} and Jeannette Maugein and Milburn, {Heather J.} and Tamas Mlink{\'o} and Nora Morcillo and Kozo Morimoto and Dimitrios Papaventsis and Elia Palenque and Mar Paez-Pe{\~n}a and Claudio Piersimoni and Monika Polanov{\'a} and Nalin Rastogi and Elvira Richter and Ruiz-Serrano, {Maria Jesus} and Anabela Silva and {Da Silva}, {M. Pedro} and Hulya Simsek and {Van Soolingen}, Dick and Nora Szab{\'o} and Rachel Thomson and Fernandez, {Teresa T{\'o}rtola} and Enrico Tortoli and Totten, {Sarah E.} and Greg Tyrrell and Tuula Vasankari and Miguel Villar and Renata Walkiewicz and Winthrop, {Kevin L.} and Dirk Wagner",

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doi = "10.1183/09031936.00149212",

language = "English (US)",

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T1 - The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples

T2 - An NTM-NET collaborative study

AU - Hoefsloot, Wouter

AU - Van Ingen, Jakko

AU - Andrejak, Claire

AU - Ängeby, Kristian

AU - Bauriaud, Rosine

AU - Bemer, Pascale

AU - Beylis, Natalie

AU - Boeree, Martin J.

AU - Cacho, Juana

AU - Chihota, Violet

AU - Chimara, Erica

AU - Churchyard, Gavin

AU - Cias, Raquel

AU - Daza, Rosa

AU - Daley, Charles L.

AU - Dekhuijzen, P. N.Richard

AU - Domingo, Diego

AU - Drobniewski, Francis

AU - Esteban, Jaime

AU - Fauville-Dufaux, Maryse

AU - Folkvardsen, Dorte Bek

AU - Gibbons, Noel

AU - Gómez-Mampaso, Enrique

AU - Gonzalez, Rosa

AU - Hoffmann, Harald

AU - Hsueh, Po Ren

AU - Indra, Alexander

AU - Jagielski, Tomasz

AU - Jamieson, Frances

AU - Jankovic, Mateja

AU - Jong, Eefje

AU - Keane, Joseph

AU - Koh, Wo Jung

AU - Lange, Berit

AU - Leao, Sylvia

AU - Macedo, Rita

AU - Mannsåker, Turid

AU - Marras, Theodore K.

AU - Maugein, Jeannette

AU - Milburn, Heather J.

AU - Mlinkó, Tamas

AU - Morcillo, Nora

AU - Morimoto, Kozo

AU - Papaventsis, Dimitrios

AU - Palenque, Elia

AU - Paez-Peña, Mar

AU - Piersimoni, Claudio

AU - Polanová, Monika

AU - Rastogi, Nalin

AU - Richter, Elvira

AU - Ruiz-Serrano, Maria Jesus

AU - Silva, Anabela

AU - Da Silva, M. Pedro

AU - Simsek, Hulya

AU - Van Soolingen, Dick

AU - Szabó, Nora

AU - Thomson, Rachel

AU - Fernandez, Teresa Tórtola

AU - Tortoli, Enrico

AU - Totten, Sarah E.

AU - Tyrrell, Greg

AU - Vasankari, Tuula

AU - Villar, Miguel

AU - Walkiewicz, Renata

AU - Winthrop, Kevin L.

AU - Wagner, Dirk

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The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: An NTM-NET collaborative study

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