The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: An NTM-NET collaborative study

Wouter Hoefsloot, Jakko Van Ingen, Claire Andrejak, Kristian Ängeby, Rosine Bauriaud, Pascale Bemer, Natalie Beylis, Martin J. Boeree, Juana Cacho, Violet Chihota, Erica Chimara, Gavin Churchyard, Raquel Cias, Rosa Daza, Charles L. Daley, P. N Richard Dekhuijzen, Diego Domingo, Francis Drobniewski, Jaime Esteban, Maryse Fauville-DufauxDorte Bek Folkvardsen, Noel Gibbons, Enrique Gómez-Mampaso, Rosa Gonzalez, Harald Hoffmann, Po Ren Hsueh, Alexander Indra, Tomasz Jagielski, Frances Jamieson, Mateja Jankovic, Eefje Jong, Joseph Keane, Wo Jung Koh, Berit Lange, Sylvia Leao, Rita Macedo, Turid Mannsåker, Theodore K. Marras, Jeannette Maugein, Heather J. Milburn, Tamas Mlinkó, Nora Morcillo, Kozo Morimoto, Dimitrios Papaventsis, Elia Palenque, Mar Paez-Peña, Claudio Piersimoni, Monika Polanová, Nalin Rastogi, Elvira Richter, Maria Jesus Ruiz-Serrano, Anabela Silva, M. Pedro Da Silva, Hulya Simsek, Dick Van Soolingen, Nora Szabó, Rachel Thomson, Teresa Tórtola Fernandez, Enrico Tortoli, Sarah E. Totten, Greg Tyrrell, Tuula Vasankari, Miguel Villar, Renata Walkiewicz, Kevin Winthrop, Dirk Wagner

Research output: Contribution to journalArticle

308 Citations (Scopus)

Abstract

A significant knowledge gap exists concerning the geographical distribution of nontuberculous mycobacteria (NTM) isolation worldwide. To provide a snapshot of NTM species distribution, global partners in the NTM-Network European Trials Group (NET) framework (www.ntm-net.org), a branch of the Tuberculosis Network European Trials Group (TB-NET), provided identification results of the total number of patients in 2008 in whom NTM were isolated from pulmonary samples. From these data, we visualised the relative distribution of the different NTM found per continent and per country. We received species identification data for 20 182 patients, from 62 laboratories in 30 countries across six continents. 91 different NTM species were isolated. Mycobacterium avium complex (MAC) bacteria predominated inmost countries, followed by M. gordonae and M. xenopi. Important differences in geographical distribution of MAC species as well as M. xenopi, M. kansasii and rapid-growing mycobacteria were observed. This snapshot demonstrates that the species distribution among NTM isolates from pulmonary specimens in the year 2008 differed by continent and differed by country within these continents. These differences in species distribution may partly determine the frequency and manifestations of pulmonary NTM disease in each geographical location.

Original languageEnglish (US)
Pages (from-to)1604-1613
Number of pages10
JournalEuropean Respiratory Journal
Volume42
Issue number6
DOIs
StatePublished - Dec 1 2013

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Nontuberculous Mycobacteria
Lung
Mycobacterium avium Complex
Gordonia Bacterium
Social Identification
Mycobacterium
Tuberculosis
Bacteria

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Hoefsloot, W., Van Ingen, J., Andrejak, C., Ängeby, K., Bauriaud, R., Bemer, P., ... Wagner, D. (2013). The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: An NTM-NET collaborative study. European Respiratory Journal, 42(6), 1604-1613. https://doi.org/10.1183/09031936.00149212

The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples : An NTM-NET collaborative study. / Hoefsloot, Wouter; Van Ingen, Jakko; Andrejak, Claire; Ängeby, Kristian; Bauriaud, Rosine; Bemer, Pascale; Beylis, Natalie; Boeree, Martin J.; Cacho, Juana; Chihota, Violet; Chimara, Erica; Churchyard, Gavin; Cias, Raquel; Daza, Rosa; Daley, Charles L.; Dekhuijzen, P. N Richard; Domingo, Diego; Drobniewski, Francis; Esteban, Jaime; Fauville-Dufaux, Maryse; Folkvardsen, Dorte Bek; Gibbons, Noel; Gómez-Mampaso, Enrique; Gonzalez, Rosa; Hoffmann, Harald; Hsueh, Po Ren; Indra, Alexander; Jagielski, Tomasz; Jamieson, Frances; Jankovic, Mateja; Jong, Eefje; Keane, Joseph; Koh, Wo Jung; Lange, Berit; Leao, Sylvia; Macedo, Rita; Mannsåker, Turid; Marras, Theodore K.; Maugein, Jeannette; Milburn, Heather J.; Mlinkó, Tamas; Morcillo, Nora; Morimoto, Kozo; Papaventsis, Dimitrios; Palenque, Elia; Paez-Peña, Mar; Piersimoni, Claudio; Polanová, Monika; Rastogi, Nalin; Richter, Elvira; Ruiz-Serrano, Maria Jesus; Silva, Anabela; Da Silva, M. Pedro; Simsek, Hulya; Van Soolingen, Dick; Szabó, Nora; Thomson, Rachel; Fernandez, Teresa Tórtola; Tortoli, Enrico; Totten, Sarah E.; Tyrrell, Greg; Vasankari, Tuula; Villar, Miguel; Walkiewicz, Renata; Winthrop, Kevin; Wagner, Dirk.

In: European Respiratory Journal, Vol. 42, No. 6, 01.12.2013, p. 1604-1613.

Research output: Contribution to journalArticle

Hoefsloot, W, Van Ingen, J, Andrejak, C, Ängeby, K, Bauriaud, R, Bemer, P, Beylis, N, Boeree, MJ, Cacho, J, Chihota, V, Chimara, E, Churchyard, G, Cias, R, Daza, R, Daley, CL, Dekhuijzen, PNR, Domingo, D, Drobniewski, F, Esteban, J, Fauville-Dufaux, M, Folkvardsen, DB, Gibbons, N, Gómez-Mampaso, E, Gonzalez, R, Hoffmann, H, Hsueh, PR, Indra, A, Jagielski, T, Jamieson, F, Jankovic, M, Jong, E, Keane, J, Koh, WJ, Lange, B, Leao, S, Macedo, R, Mannsåker, T, Marras, TK, Maugein, J, Milburn, HJ, Mlinkó, T, Morcillo, N, Morimoto, K, Papaventsis, D, Palenque, E, Paez-Peña, M, Piersimoni, C, Polanová, M, Rastogi, N, Richter, E, Ruiz-Serrano, MJ, Silva, A, Da Silva, MP, Simsek, H, Van Soolingen, D, Szabó, N, Thomson, R, Fernandez, TT, Tortoli, E, Totten, SE, Tyrrell, G, Vasankari, T, Villar, M, Walkiewicz, R, Winthrop, K & Wagner, D 2013, 'The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: An NTM-NET collaborative study', European Respiratory Journal, vol. 42, no. 6, pp. 1604-1613. https://doi.org/10.1183/09031936.00149212
Hoefsloot, Wouter ; Van Ingen, Jakko ; Andrejak, Claire ; Ängeby, Kristian ; Bauriaud, Rosine ; Bemer, Pascale ; Beylis, Natalie ; Boeree, Martin J. ; Cacho, Juana ; Chihota, Violet ; Chimara, Erica ; Churchyard, Gavin ; Cias, Raquel ; Daza, Rosa ; Daley, Charles L. ; Dekhuijzen, P. N Richard ; Domingo, Diego ; Drobniewski, Francis ; Esteban, Jaime ; Fauville-Dufaux, Maryse ; Folkvardsen, Dorte Bek ; Gibbons, Noel ; Gómez-Mampaso, Enrique ; Gonzalez, Rosa ; Hoffmann, Harald ; Hsueh, Po Ren ; Indra, Alexander ; Jagielski, Tomasz ; Jamieson, Frances ; Jankovic, Mateja ; Jong, Eefje ; Keane, Joseph ; Koh, Wo Jung ; Lange, Berit ; Leao, Sylvia ; Macedo, Rita ; Mannsåker, Turid ; Marras, Theodore K. ; Maugein, Jeannette ; Milburn, Heather J. ; Mlinkó, Tamas ; Morcillo, Nora ; Morimoto, Kozo ; Papaventsis, Dimitrios ; Palenque, Elia ; Paez-Peña, Mar ; Piersimoni, Claudio ; Polanová, Monika ; Rastogi, Nalin ; Richter, Elvira ; Ruiz-Serrano, Maria Jesus ; Silva, Anabela ; Da Silva, M. Pedro ; Simsek, Hulya ; Van Soolingen, Dick ; Szabó, Nora ; Thomson, Rachel ; Fernandez, Teresa Tórtola ; Tortoli, Enrico ; Totten, Sarah E. ; Tyrrell, Greg ; Vasankari, Tuula ; Villar, Miguel ; Walkiewicz, Renata ; Winthrop, Kevin ; Wagner, Dirk. / The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples : An NTM-NET collaborative study. In: European Respiratory Journal. 2013 ; Vol. 42, No. 6. pp. 1604-1613.
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abstract = "A significant knowledge gap exists concerning the geographical distribution of nontuberculous mycobacteria (NTM) isolation worldwide. To provide a snapshot of NTM species distribution, global partners in the NTM-Network European Trials Group (NET) framework (www.ntm-net.org), a branch of the Tuberculosis Network European Trials Group (TB-NET), provided identification results of the total number of patients in 2008 in whom NTM were isolated from pulmonary samples. From these data, we visualised the relative distribution of the different NTM found per continent and per country. We received species identification data for 20 182 patients, from 62 laboratories in 30 countries across six continents. 91 different NTM species were isolated. Mycobacterium avium complex (MAC) bacteria predominated inmost countries, followed by M. gordonae and M. xenopi. Important differences in geographical distribution of MAC species as well as M. xenopi, M. kansasii and rapid-growing mycobacteria were observed. This snapshot demonstrates that the species distribution among NTM isolates from pulmonary specimens in the year 2008 differed by continent and differed by country within these continents. These differences in species distribution may partly determine the frequency and manifestations of pulmonary NTM disease in each geographical location.",
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AU - Bemer, Pascale

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