The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

Leng Han, Lixia Diao, Shuangxing Yu, Xiaoyan Xu, Jie Li, Rui Zhang, Yang Yang, Henrica M.J. Werner, A. Karina Eterovic, Yuan Yuan, Jun Li, Nikitha Nair, Rosalba Minelli, Yiu Huen Tsang, Lydia W.T. Cheung, Kang Jin Jeong, Jason Roszik, Zhenlin Ju, Scott E. Woodman, Yiling LuKenneth L. Scott, Jin Billy Li, Gordon Mills, Han Liang

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional mechanism, but its genomic landscape and clinical relevance in cancer have not been investigated systematically. We characterized the global A-to-I RNA editing profiles of 6,236 patient samples of 17 cancer types from The Cancer Genome Atlas and revealed a striking diversity of altered RNA-editing patterns in tumors relative to normal tissues. We identified an appreciable number of clinically relevant editing events, many of which are in noncoding regions. We experimentally demonstrated the effects of several cross-tumor nonsynonymous RNA editing events on cell viability and provide the evidence that RNA editing could selectively affect drug sensitivity. These results highlight RNA editing as an exciting theme for investigating cancer mechanisms, biomarkers, and treatments.

Original languageEnglish (US)
Article number2143
Pages (from-to)515-528
Number of pages14
JournalCancer Cell
Volume28
Issue number4
DOIs
StatePublished - Oct 12 2015
Externally publishedYes

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RNA Editing
Inosine
Adenosine
Neoplasms
Atlases
Tumor Biomarkers
Cell Survival
Genome
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Han, L., Diao, L., Yu, S., Xu, X., Li, J., Zhang, R., ... Liang, H. (2015). The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers. Cancer Cell, 28(4), 515-528. [2143]. https://doi.org/10.1016/j.ccell.2015.08.013

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers. / Han, Leng; Diao, Lixia; Yu, Shuangxing; Xu, Xiaoyan; Li, Jie; Zhang, Rui; Yang, Yang; Werner, Henrica M.J.; Eterovic, A. Karina; Yuan, Yuan; Li, Jun; Nair, Nikitha; Minelli, Rosalba; Tsang, Yiu Huen; Cheung, Lydia W.T.; Jeong, Kang Jin; Roszik, Jason; Ju, Zhenlin; Woodman, Scott E.; Lu, Yiling; Scott, Kenneth L.; Li, Jin Billy; Mills, Gordon; Liang, Han.

In: Cancer Cell, Vol. 28, No. 4, 2143, 12.10.2015, p. 515-528.

Research output: Contribution to journalArticle

Han, L, Diao, L, Yu, S, Xu, X, Li, J, Zhang, R, Yang, Y, Werner, HMJ, Eterovic, AK, Yuan, Y, Li, J, Nair, N, Minelli, R, Tsang, YH, Cheung, LWT, Jeong, KJ, Roszik, J, Ju, Z, Woodman, SE, Lu, Y, Scott, KL, Li, JB, Mills, G & Liang, H 2015, 'The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers', Cancer Cell, vol. 28, no. 4, 2143, pp. 515-528. https://doi.org/10.1016/j.ccell.2015.08.013
Han, Leng ; Diao, Lixia ; Yu, Shuangxing ; Xu, Xiaoyan ; Li, Jie ; Zhang, Rui ; Yang, Yang ; Werner, Henrica M.J. ; Eterovic, A. Karina ; Yuan, Yuan ; Li, Jun ; Nair, Nikitha ; Minelli, Rosalba ; Tsang, Yiu Huen ; Cheung, Lydia W.T. ; Jeong, Kang Jin ; Roszik, Jason ; Ju, Zhenlin ; Woodman, Scott E. ; Lu, Yiling ; Scott, Kenneth L. ; Li, Jin Billy ; Mills, Gordon ; Liang, Han. / The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers. In: Cancer Cell. 2015 ; Vol. 28, No. 4. pp. 515-528.
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