The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits

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Abstract

Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of these issues is discussed, providing an initial framework for complex cross study design and planning.

Original languageEnglish (US)
Pages (from-to)12-22
Number of pages11
JournalMammalian Genome
Volume25
Issue number1-2
DOIs
StatePublished - 2014

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Gene Expression

ASJC Scopus subject areas

  • Genetics

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title = "The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits",
abstract = "Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of these issues is discussed, providing an initial framework for complex cross study design and planning.",
author = "Robert Hitzemann and Daniel Bottomly and Ovidiu Iancu and Kari Buck and Beth Wilmot and Michael Mooney and Robert Searles and Christina Zheng and John Belknap and Crabbe, {John Jr} and Shannon McWeeney",
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AU - Hitzemann, Robert

AU - Bottomly, Daniel

AU - Iancu, Ovidiu

AU - Buck, Kari

AU - Wilmot, Beth

AU - Mooney, Michael

AU - Searles, Robert

AU - Zheng, Christina

AU - Belknap, John

AU - Crabbe, John Jr

AU - McWeeney, Shannon

PY - 2014

Y1 - 2014

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AB - Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of these issues is discussed, providing an initial framework for complex cross study design and planning.

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