The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits

Robert Hitzemann, Daniel Bottomly, Ovidiu Iancu, Kari Buck, Beth Wilmot, Michael Mooney, Robert Searles, Christina Zheng, John Belknap, John Crabbe, Shannon McWeeney

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of these issues is discussed, providing an initial framework for complex cross study design and planning.

Original languageEnglish (US)
Pages (from-to)12-22
Number of pages11
JournalMammalian Genome
Volume25
Issue number1-2
DOIs
StatePublished - Feb 2014

ASJC Scopus subject areas

  • Genetics

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