The Genetic Complexity of Alcohol Drinking in Rodents

John C. Crabbe

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


This chapter first discusses the alcohol-drinking phenotypes most commonly used in rodent genetic studies. The emphasis is on the complexity of the phenotypic spaces encompassed by the drinking assays (many of which are amalgamations of multiple approaches). It then reviews the evidence for genetic contributions to those drinking traits. For several of them, there is unequivocal evidence for genetic contributions to individual differences in drinking, and for one of them, two-bottle preference drinking, there are voluminous data. Finally, it discusses the genetic singularity of each trait versus what appear to be pleiotropic genetic influences (those in which one or more genes influence multiple traits related to drinking). Sorting out this genetic complexity is difficult because genetic information is sparse for many drinking-related behaviors, and many procedures are used in combination with others.

Original languageEnglish (US)
Title of host publicationNeurobiology of Alcohol Dependence
PublisherElsevier Inc.
Number of pages17
ISBN (Print)9780124059412
StatePublished - Feb 2014
Externally publishedYes


  • Alcohol preference
  • Alcohol withdrawal
  • Drinking in the dark
  • HDID mice
  • Inbred strains
  • Selective breeding

ASJC Scopus subject areas

  • Neuroscience(all)


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