The Genetic Complexity of Alcohol Drinking in Rodents

John C. Crabbe

doi:10.1016/B978-0-12-405941-2.00018-3

The Genetic Complexity of Alcohol Drinking in Rodents

John C. Crabbe

Research output: Chapter in Book/Report/Conference proceeding › Chapter

6 Scopus citations

Abstract

This chapter first discusses the alcohol-drinking phenotypes most commonly used in rodent genetic studies. The emphasis is on the complexity of the phenotypic spaces encompassed by the drinking assays (many of which are amalgamations of multiple approaches). It then reviews the evidence for genetic contributions to those drinking traits. For several of them, there is unequivocal evidence for genetic contributions to individual differences in drinking, and for one of them, two-bottle preference drinking, there are voluminous data. Finally, it discusses the genetic singularity of each trait versus what appear to be pleiotropic genetic influences (those in which one or more genes influence multiple traits related to drinking). Sorting out this genetic complexity is difficult because genetic information is sparse for many drinking-related behaviors, and many procedures are used in combination with others.

Original language	English (US)
Title of host publication	Neurobiology of Alcohol Dependence
Publisher	Elsevier Inc.
Pages	359-375
Number of pages	17
ISBN (Print)	9780124059412
DOIs	https://doi.org/10.1016/B978-0-12-405941-2.00018-3
State	Published - Feb 2014
Externally published	Yes

Keywords

Alcohol preference
Alcohol withdrawal
Drinking in the dark
HDID mice
Inbred strains
Selective breeding

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/B978-0-12-405941-2.00018-3

Cite this

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title = "The Genetic Complexity of Alcohol Drinking in Rodents",

abstract = "This chapter first discusses the alcohol-drinking phenotypes most commonly used in rodent genetic studies. The emphasis is on the complexity of the phenotypic spaces encompassed by the drinking assays (many of which are amalgamations of multiple approaches). It then reviews the evidence for genetic contributions to those drinking traits. For several of them, there is unequivocal evidence for genetic contributions to individual differences in drinking, and for one of them, two-bottle preference drinking, there are voluminous data. Finally, it discusses the genetic singularity of each trait versus what appear to be pleiotropic genetic influences (those in which one or more genes influence multiple traits related to drinking). Sorting out this genetic complexity is difficult because genetic information is sparse for many drinking-related behaviors, and many procedures are used in combination with others.",

keywords = "Alcohol preference, Alcohol withdrawal, Drinking in the dark, HDID mice, Inbred strains, Selective breeding",

author = "Crabbe, {John C.}",

note = "Funding Information: Preparation of this paper was supported by the US Department of Veterans Affairs, the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health (Grants AA10760 , AA13519 , and AA20245 ), and the US Department of the Army/DoD-TATRC Grant 10235005.05 . I thank Howard Becker for his helpful comments on this MS. ",

year = "2014",

month = feb,

doi = "10.1016/B978-0-12-405941-2.00018-3",

language = "English (US)",

isbn = "9780124059412",

pages = "359--375",

booktitle = "Neurobiology of Alcohol Dependence",

publisher = "Elsevier Inc.",

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AU - Crabbe, John C.

N1 - Funding Information: Preparation of this paper was supported by the US Department of Veterans Affairs, the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health (Grants AA10760 , AA13519 , and AA20245 ), and the US Department of the Army/DoD-TATRC Grant 10235005.05 . I thank Howard Becker for his helpful comments on this MS.

PY - 2014/2

Y1 - 2014/2

N2 - This chapter first discusses the alcohol-drinking phenotypes most commonly used in rodent genetic studies. The emphasis is on the complexity of the phenotypic spaces encompassed by the drinking assays (many of which are amalgamations of multiple approaches). It then reviews the evidence for genetic contributions to those drinking traits. For several of them, there is unequivocal evidence for genetic contributions to individual differences in drinking, and for one of them, two-bottle preference drinking, there are voluminous data. Finally, it discusses the genetic singularity of each trait versus what appear to be pleiotropic genetic influences (those in which one or more genes influence multiple traits related to drinking). Sorting out this genetic complexity is difficult because genetic information is sparse for many drinking-related behaviors, and many procedures are used in combination with others.

AB - This chapter first discusses the alcohol-drinking phenotypes most commonly used in rodent genetic studies. The emphasis is on the complexity of the phenotypic spaces encompassed by the drinking assays (many of which are amalgamations of multiple approaches). It then reviews the evidence for genetic contributions to those drinking traits. For several of them, there is unequivocal evidence for genetic contributions to individual differences in drinking, and for one of them, two-bottle preference drinking, there are voluminous data. Finally, it discusses the genetic singularity of each trait versus what appear to be pleiotropic genetic influences (those in which one or more genes influence multiple traits related to drinking). Sorting out this genetic complexity is difficult because genetic information is sparse for many drinking-related behaviors, and many procedures are used in combination with others.

KW - Alcohol preference

KW - Alcohol withdrawal

KW - Drinking in the dark

KW - HDID mice

KW - Inbred strains

KW - Selective breeding

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U2 - 10.1016/B978-0-12-405941-2.00018-3

DO - 10.1016/B978-0-12-405941-2.00018-3

M3 - Chapter

AN - SCOPUS:84902388826

SN - 9780124059412

SP - 359

EP - 375

BT - Neurobiology of Alcohol Dependence

PB - Elsevier Inc.

ER -

The Genetic Complexity of Alcohol Drinking in Rodents

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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