The genetic basis of delay discounting and its genetic relationship to alcohol dependence

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Delay discounting is steeper for individuals who drink heavily or are alcohol dependent, but the reasons for this are unclear. Given the substantial genetic component for alcohol dependence it is not unreasonable to ask whether discounting and alcohol dependence have a genetic relationship. For there to be a genetic relationship, delay discounting must have a genetic component (heritability). A review of the human and animal literature suggests that this is the case. Other literature examining whether discounting is a correlated phenotype in individuals who are genetically predisposed to drink (family history positive individuals and selected lines of rats and mice) is mixed, suggesting that networks of genes are critical for the relationship to be seen. The identities of the genes in this network are not yet known, but research examining polymorphisms associated with differences in discounting is beginning to address this issue.

Original languageEnglish (US)
Pages (from-to)10-17
Number of pages8
JournalBehavioural Processes
Volume87
Issue number1
DOIs
StatePublished - May 2011

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Gene Regulatory Networks
alcohol abuse
Alcoholism
genetic relationships
heritability
alcohols
Alcohols
genetic polymorphism
Phenotype
phenotype
rats
mice
Research
animals
gene regulatory networks
Delay Discounting

Keywords

  • Alcohol dependence
  • Delay discounting
  • Genetics
  • Human
  • Mouse
  • Rat

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Behavioral Neuroscience

Cite this

The genetic basis of delay discounting and its genetic relationship to alcohol dependence. / Mitchell, Suzanne.

In: Behavioural Processes, Vol. 87, No. 1, 05.2011, p. 10-17.

Research output: Contribution to journalArticle

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