The gene for familial dystonia with myoclonic jerks responsive to alcohol is not located on the distal end of 9q

J. Wahlstrom, L. Ozelius, P. Kramer, M. Kyllerman, D. Schuback, L. Forsgren, G. Holmgren, U. Drugge, G. Sanner, S. Fahn, X. O. Breakefield

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A gene (DYT1) for susceptibility to early-onset torsion dystonia in Ashkenazi Jewish and Gentile kindreds is situated on chromosome 9q32-q34 in a 6-7 cM span between markers AK1 and ASS. To determine whether transmission of familial dystonia with myoclonic jerks responsive to alcohol was consistent with a gene in this region, we studied the 37 members of a Swedish family, of whom 20 were so affected. A lod score of <-2.00 from a two-point linkage analysis with six DNA markers covering a 30 cM span from D9S26 to D9S10 that included the region of the DYT gene indicated that this gene is not located in this region, and that two or more autosomal loci are responsible for hereditary dystonia in humans.

Original languageEnglish (US)
Pages (from-to)88-92
Number of pages5
JournalClinical Genetics
Volume45
Issue number2
StatePublished - 1994
Externally publishedYes

Fingerprint

Dystonic Disorders
Myoclonus
Alcohols
Genes
Lod Score
Genetic Markers
Chromosomes

Keywords

  • Chromosome 9
  • Linkage analysis
  • Torsion dystonia

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Wahlstrom, J., Ozelius, L., Kramer, P., Kyllerman, M., Schuback, D., Forsgren, L., ... Breakefield, X. O. (1994). The gene for familial dystonia with myoclonic jerks responsive to alcohol is not located on the distal end of 9q. Clinical Genetics, 45(2), 88-92.

The gene for familial dystonia with myoclonic jerks responsive to alcohol is not located on the distal end of 9q. / Wahlstrom, J.; Ozelius, L.; Kramer, P.; Kyllerman, M.; Schuback, D.; Forsgren, L.; Holmgren, G.; Drugge, U.; Sanner, G.; Fahn, S.; Breakefield, X. O.

In: Clinical Genetics, Vol. 45, No. 2, 1994, p. 88-92.

Research output: Contribution to journalArticle

Wahlstrom, J, Ozelius, L, Kramer, P, Kyllerman, M, Schuback, D, Forsgren, L, Holmgren, G, Drugge, U, Sanner, G, Fahn, S & Breakefield, XO 1994, 'The gene for familial dystonia with myoclonic jerks responsive to alcohol is not located on the distal end of 9q', Clinical Genetics, vol. 45, no. 2, pp. 88-92.
Wahlstrom J, Ozelius L, Kramer P, Kyllerman M, Schuback D, Forsgren L et al. The gene for familial dystonia with myoclonic jerks responsive to alcohol is not located on the distal end of 9q. Clinical Genetics. 1994;45(2):88-92.
Wahlstrom, J. ; Ozelius, L. ; Kramer, P. ; Kyllerman, M. ; Schuback, D. ; Forsgren, L. ; Holmgren, G. ; Drugge, U. ; Sanner, G. ; Fahn, S. ; Breakefield, X. O. / The gene for familial dystonia with myoclonic jerks responsive to alcohol is not located on the distal end of 9q. In: Clinical Genetics. 1994 ; Vol. 45, No. 2. pp. 88-92.
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AU - Schuback, D.

AU - Forsgren, L.

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