The Gα protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons

Kayvan Roayaie, Justin Gage Crump, Alvaro Sagasti, Cornelia I. Bargmann

Research output: Contribution to journalArticle

222 Scopus citations

Abstract

The G1/G0-like Gα protein ODR-3 is strongly and selectively implicated in the function of C. elegans olfactory and nociceptive neurons. Either loss of odr-3 function or overexpression of odr-3 causes severe olfactory defects, and odr-3 function is essential in the ASH neurons that sense noxious chemical and mechanical stimuli. In the nociceptive neurons, ODR-3 may interact with OSM-9, a channel similar to the mammalian capsaicin receptor implicated in pain sensation; in AWC olfactory neurons, ODR-3 may interact with another signal transduction pathway. ODR-3 exhibits an unexpected ability to regulate morphogenesis of the olfactory cilia. In odr- 3 null mutants, the fan-like AWC cilia take on a filamentous morphology like normal AWA cilia, whereas ODR-3 overexpression in AWA transforms its filamentous cilia into a fan-like morphology.

Original languageEnglish (US)
Pages (from-to)55-67
Number of pages13
JournalNeuron
Volume20
Issue number1
DOIs
StatePublished - Jan 1998

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'The Gα protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons'. Together they form a unique fingerprint.

  • Cite this