The functions of herpesvirus-encoded microRNAs

Finn Grey, Lauren Hook, Jay Nelson

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Bioinformatic and direct cloning approaches have led to the identification of over 100 novel miRNAs expressed in DNA viruses, although the function of the majority of these small regulatory RNA molecules is unclear. Recently, a number of reports have now identified potential targets of viral miRNAs, including cellular and viral genes as well as an ortholog of an important immuno-regulatory cellular miRNA. In this review, we will cover the identification and characterization of miRNAs expressed in the herpesvirus family and discuss the potential significance of their role in viral infection.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalMedical Microbiology and Immunology
Volume197
Issue number2
DOIs
Publication statusPublished - Jun 2008

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Keywords

  • EBV
  • HCMV
  • Herpesvirus
  • HSV
  • KSHV
  • microRNA
  • miRNA
  • Virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology

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