The functions of antigen recognition in T cell-dependent B cell activation

David C. Parker

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


B cells get help from T cells by acting as antigen-specific APC. A signal from the B cell antigen receptor is not required for efficient antigen presentation or for the B cell response to T cell help. T cells provide help by making lymphokines, some of which, like CD40 ligand, remain T cell-associated and require cell contact for function. The function of class II MHC is to induce help in the T cell, rather than to deliver help to the B cell. T cell help uses different intracellular signaling pathways from those engaged by the B cell antigen receptor.

Original languageEnglish (US)
Pages (from-to)413-420
Number of pages8
JournalSeminars in Immunology
Issue number6
StatePublished - 1993
Externally publishedYes


  • Antigen receptor
  • B lymphocyte
  • Help
  • Signaling
  • T lymphocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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