Abstract
B cells get help from T cells by acting as antigen-specific APC. A signal from the B cell antigen receptor is not required for efficient antigen presentation or for the B cell response to T cell help. T cells provide help by making lymphokines, some of which, like CD40 ligand, remain T cell-associated and require cell contact for function. The function of class II MHC is to induce help in the T cell, rather than to deliver help to the B cell. T cell help uses different intracellular signaling pathways from those engaged by the B cell antigen receptor.
Original language | English (US) |
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Pages (from-to) | 413-420 |
Number of pages | 8 |
Journal | Seminars in Immunology |
Volume | 5 |
Issue number | 6 |
DOIs | |
State | Published - 1993 |
Externally published | Yes |
Keywords
- Antigen receptor
- B lymphocyte
- Help
- Signaling
- T lymphocyte
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology