TY - JOUR
T1 - The function and regulation of the primate corpus luteum during the fertile menstrual cycle.
AU - Stouffer, R. L.
AU - Ottobre, J. S.
AU - Molskness, T. A.
AU - Zelinski-Wooten, M. B.
PY - 1989
Y1 - 1989
N2 - Figure 2 summarizes the changes in endocrine function and the factors which regulate the primate corpus luteum during the fertile menstrual cycle. The classical luteotropic role of LH during the menstrual cycle is superceded by CG at or before the time of implantation. The role of local factors in modulating luteal function is an area of continued research, as some factors are deemed less important (i.e., estrogen, at least prior to luteal rescue) and other possibilities (progesterone, prostaglandins, and relaxin) arise. The role of local factors has not yet been studied in the corpus luteum following its rescue in early pregnancy. Finally, it is apparent that a different type of "shift" precedes the recognized luteal-placental shift in early pregnancy, when the corpus luteum enhances or begins new activities as progesterone secretion declines. These new or augmented activities occur despite apparent desensitization of CG-responsive cAMP-mediated pathways in luteal cells. Although the cellular events promoting these changes are not known, it seems reasonable to propose that the resulting products, including estrogen (as discussed in Dr. Moudgal's chapter) and relaxin are important in early pregnancy. Thus the term "luteal-placental shift" may be a misnomer, as other activities which promote gestation continue within the corpus luteum for a limited time.
AB - Figure 2 summarizes the changes in endocrine function and the factors which regulate the primate corpus luteum during the fertile menstrual cycle. The classical luteotropic role of LH during the menstrual cycle is superceded by CG at or before the time of implantation. The role of local factors in modulating luteal function is an area of continued research, as some factors are deemed less important (i.e., estrogen, at least prior to luteal rescue) and other possibilities (progesterone, prostaglandins, and relaxin) arise. The role of local factors has not yet been studied in the corpus luteum following its rescue in early pregnancy. Finally, it is apparent that a different type of "shift" precedes the recognized luteal-placental shift in early pregnancy, when the corpus luteum enhances or begins new activities as progesterone secretion declines. These new or augmented activities occur despite apparent desensitization of CG-responsive cAMP-mediated pathways in luteal cells. Although the cellular events promoting these changes are not known, it seems reasonable to propose that the resulting products, including estrogen (as discussed in Dr. Moudgal's chapter) and relaxin are important in early pregnancy. Thus the term "luteal-placental shift" may be a misnomer, as other activities which promote gestation continue within the corpus luteum for a limited time.
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M3 - Review article
C2 - 2657776
AN - SCOPUS:0024491873
SN - 0361-7742
VL - 294
SP - 129
EP - 142
JO - Progress in clinical and biological research
JF - Progress in clinical and biological research
ER -