The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation?

Gerhard Sengle, Lynn Sakai

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

The fibrillins, large extracellular matrix molecules, are polymerized to form "microfibrils." The fibrillin microfibril scaffold is populated by microfibril-associated proteins and by growth factors, which are likely to be latent. The scaffold, associated proteins, and bound growth factors, together with cellular receptors that can sense the microfibril matrix, constitute the fibrillin microenvironment. Activation of TGFβ signaling is associated with the Marfan syndrome, which is caused by mutations in fibrillin-1. Today we know that mutations in fibrillin-1 cause the Marfan syndrome as well as Weill-Marchesani syndrome (and other acromelic dysplasias) and result in opposite clinical phenotypes: tall or short stature; arachnodactyly or brachydactyly; joint hypermobility or stiff joints; hypomuscularity or hypermuscularity. We also know that these different syndromes are associated with different structural abnormalities in the fibrillin microfibril scaffold and perhaps with specific cellular receptors (mechanosensors). How does the microenvironment, framed by the microfibril scaffold and populated by latent growth factors, work? We must await future investigations for the molecular and cellular mechanisms that will answer this question. However, today we can appreciate the importance of the fibrillin microfibril niche as a contextual environment for growth factor signaling and potentially for mechanosensation.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalMatrix Biology
Volume47
DOIs
StatePublished - Sep 1 2015

Fingerprint

Microfibrils
Intercellular Signaling Peptides and Proteins
Marfan Syndrome
Weill-Marchesani Syndrome
Arachnodactyly
Brachydactyly
Joint Instability
Mutation
Fibrillins
Extracellular Matrix
Proteins
Joints
Phenotype

Keywords

  • Bone morphogenetic protein
  • Fibrillin
  • LTBP
  • Marfan syndrome
  • Mechanosensation
  • TGFβ
  • Weill-Marchesani syndrome

ASJC Scopus subject areas

  • Molecular Biology

Cite this

The fibrillin microfibril scaffold : A niche for growth factors and mechanosensation? / Sengle, Gerhard; Sakai, Lynn.

In: Matrix Biology, Vol. 47, 01.09.2015, p. 3-12.

Research output: Contribution to journalReview article

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