TY - JOUR
T1 - The feasibility of using thermal strain imaging to regulate energy delivery during intracardiac radio-frequency ablation
AU - Seo, Chi Hyung
AU - Stephens, Douglas N.
AU - Cannata, Jonathan
AU - Dentinger, Aaron
AU - Lin, Feng
AU - Park, Suhyun
AU - Wildes, Douglas
AU - Thomenius, Kai E.
AU - Chen, Peter
AU - Nguyen, Tho
AU - De La Rama, Alan
AU - Jeong, Jong Seob
AU - Mahajan, Aman
AU - Shivkumar, Kalyanam
AU - Nikoozadeh, Amin
AU - Oralkan, Omer
AU - Truong, Uyen
AU - Sahn, David J.
AU - Khuri-Yakub, Pierre T.
AU - O'Donnell, Matthew
PY - 2011/7
Y1 - 2011/7
N2 - A method is introduced to monitor cardiac ablative therapy by examining slope changes in the thermal strain curve caused by speed of sound variations with temperature. The sound speed of water-bearing tissue such as cardiac muscle increases with temperature. However, at temperatures above about 50°C, there is no further increase in the sound speed and the temperature coefficient may become slightly negative. For ablation therapy, an irreversible injury to tissue and a complete heart block occurs in the range of 48 to 50°C for a short period in accordance with the well-known Arrhenius equation. Using these two properties, we propose a potential tool to detect the moment when tissue damage occurs by using the reduced slope in the thermal strain curve as a function of heating time. We have illustrated the feasibility of this method initially using porcine myocardium in vitro. The method was further demonstrated in vivo, using a specially equipped ablation tip and an 11-MHz microlinear intracardiac echocardiography (ICE) array mounted on the tip of a catheter. The thermal strain curves showed a plateau, strongly suggesting that the temperature reached at least 50°C.
AB - A method is introduced to monitor cardiac ablative therapy by examining slope changes in the thermal strain curve caused by speed of sound variations with temperature. The sound speed of water-bearing tissue such as cardiac muscle increases with temperature. However, at temperatures above about 50°C, there is no further increase in the sound speed and the temperature coefficient may become slightly negative. For ablation therapy, an irreversible injury to tissue and a complete heart block occurs in the range of 48 to 50°C for a short period in accordance with the well-known Arrhenius equation. Using these two properties, we propose a potential tool to detect the moment when tissue damage occurs by using the reduced slope in the thermal strain curve as a function of heating time. We have illustrated the feasibility of this method initially using porcine myocardium in vitro. The method was further demonstrated in vivo, using a specially equipped ablation tip and an 11-MHz microlinear intracardiac echocardiography (ICE) array mounted on the tip of a catheter. The thermal strain curves showed a plateau, strongly suggesting that the temperature reached at least 50°C.
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U2 - 10.1109/TUFFC.2011.1960
DO - 10.1109/TUFFC.2011.1960
M3 - Article
C2 - 21768025
AN - SCOPUS:79960489203
SN - 0885-3010
VL - 58
SP - 1406
EP - 1417
JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
IS - 7
M1 - 5953996
ER -