The fatty acid composition of diacylglycerols determines local signaling patterns

André Nadler, Gregor Reither, Suihan Feng, Frank Stein, Sabine Reither, Rainer Müller, Carsten Schultz

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Caged compounds are designed to release biologically active signaling molecules with temporal, spatial, and even subcellular resolution. But how localized does the signal stay? Using the example of diacylglycerol, some signal responses (PKC) are shown to remain spatially distinct while other signals ([Ca2+]i) spread across the entire cell. Surprisingly, this distribution patterns depend on the fatty acid composition of the lipid species.

Original languageEnglish (US)
Pages (from-to)6330-6334
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number24
DOIs
StatePublished - Jun 10 2013

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Keywords

  • caged lipids
  • diacylglycerol
  • fatty acid composition
  • protein kinase C
  • signaling networks

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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