The fatty acid composition of diacylglycerols determines local signaling patterns

André Nadler; Gregor Reither; Suihan Feng; Frank Stein; Sabine Reither; Rainer Müller; Carsten Schultz

doi:10.1002/anie.201301716

The fatty acid composition of diacylglycerols determines local signaling patterns

André Nadler, Gregor Reither, Suihan Feng, Frank Stein, Sabine Reither, Rainer Müller, Carsten Schultz

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Caged compounds are designed to release biologically active signaling molecules with temporal, spatial, and even subcellular resolution. But how localized does the signal stay? Using the example of diacylglycerol, some signal responses (PKC) are shown to remain spatially distinct while other signals ([Ca²⁺]_i) spread across the entire cell. Surprisingly, this distribution patterns depend on the fatty acid composition of the lipid species.

Original language	English (US)
Pages (from-to)	6330-6334
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	24
DOIs	https://doi.org/10.1002/anie.201301716
State	Published - Jun 10 2013
Externally published	Yes

Keywords

caged lipids
diacylglycerol
fatty acid composition
protein kinase C
signaling networks

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201301716

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AU - Stein, Frank

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AU - Müller, Rainer

AU - Schultz, Carsten

PY - 2013/6/10

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AB - Caged compounds are designed to release biologically active signaling molecules with temporal, spatial, and even subcellular resolution. But how localized does the signal stay? Using the example of diacylglycerol, some signal responses (PKC) are shown to remain spatially distinct while other signals ([Ca2+]i) spread across the entire cell. Surprisingly, this distribution patterns depend on the fatty acid composition of the lipid species.

KW - caged lipids

KW - diacylglycerol

KW - fatty acid composition

KW - protein kinase C

KW - signaling networks

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The fatty acid composition of diacylglycerols determines local signaling patterns

Abstract

Keywords

ASJC Scopus subject areas

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