The fate of Schwann cells isolated from axonal contact

Harold J. Weinberg, Peter Spencer

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Chronically denervated rat and rabbit tibial nerve distal stumps were studied 3-58 weeks following nerve transaction. Schwann cells, macrophages and possibly fibroblasts participated in myelin removal which was largely complete by seven weeks. Degenerating myelinated and unmyelinated fibres developed respectively into circular and flattened columns of Schwann cell processes each delimited by a basal lamina. Schwann cell columns became encircled by fibroblasts and later by cells of perineurial type, underwent shrinkage with time and eventually were replaced by connective tissue. In another experiment, endoneurial tissue was removed from rabbit tibial nerve stumps seven weeks after transection and transplanted between the corneal stroma of the same animal for 2-6 weeks. In this locus, Schwann cells developed a thickened basal lamina and then underwent necrosis. It was concluded that the maintenance of Schwann cells in bands of Büngner is in part dependent on axonal contact and that failure of reinnervation eventually causes the columns of Schwann cells to disappear.

Original languageEnglish (US)
Pages (from-to)555-569
Number of pages15
JournalJournal of Neurocytology
Volume7
Issue number5
DOIs
StatePublished - Oct 1978
Externally publishedYes

Fingerprint

Schwann Cells
Tibial Nerve
Basement Membrane
Fibroblasts
Rabbits
Corneal Stroma
Myelin Sheath
Connective Tissue
Necrosis
Macrophages
Maintenance

ASJC Scopus subject areas

  • Neuroscience(all)
  • Histology
  • Anatomy
  • Cell Biology

Cite this

The fate of Schwann cells isolated from axonal contact. / Weinberg, Harold J.; Spencer, Peter.

In: Journal of Neurocytology, Vol. 7, No. 5, 10.1978, p. 555-569.

Research output: Contribution to journalArticle

Weinberg, Harold J. ; Spencer, Peter. / The fate of Schwann cells isolated from axonal contact. In: Journal of Neurocytology. 1978 ; Vol. 7, No. 5. pp. 555-569.
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